Cochrane · systematic review · CD013534
Skin care interventions in infants for preventing eczema and food allergy
Kelleher, MM, Phillips, R, Brown, SJ, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 62.5%Moderate 3 · 37.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlySkin care intervention compared to standard skin care or no skin care intervention for the prevention of eczema and food allergy
Population: infants age 12 months or younger
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Eczema diagnosis by 1 to 3 years Skin care intervention vs standard skin care or no skin care intervention | RR 1.03 [0.81, 1.31] | 7 studies · 3075 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
IgE‐mediated food allergy (oral food challenge) by 1 to 3 years Skin care intervention vs standard skin care or no skin care intervention | RR 2.53 [0.99, 6.49] | 1 study · 976 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Slippages (over the intervention period) Skin care intervention vs standard skin care or no skin care intervention | RR 1.42 [0.67, 2.99] | 4 studies · 2538 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Skin infection (over the intervention period) Skin care intervention vs standard skin care or no skin care intervention | RR 1.33 [1.01, 1.75] | 6 studies · 2728 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Stinging/allergic reactions to moisturisers (over the intervention period) Skin care intervention vs standard skin care or no skin care intervention | RR 2.24 [0.67, 7.43] | 4 studies · 343 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Time to onset of eczema Skin care intervention vs standard skin care or no skin care intervention | HR 0.86 [0.65, 1.14] | 9 studies · 3349 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Parent report of immediate reaction to common food allergen (at 2 years) Skin care intervention vs standard skin care or no skin care intervention | RR 1.27 [1, 1.61] | 1 study · 1171 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Allergic sensitisation to a food allergen (at 1 to 3 years) Skin care intervention vs standard skin care or no skin care intervention | RR 1.05 [0.64, 1.71] | 3 studies · 1794 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Skin care intervention compared to standard skin care or no skin care intervention for the prevention of eczema and food allergy
Population: infants age 12 months or younger
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Eczema diagnosis by 1 to 2 years Skin care intervention vs standard skin care or no skin care intervention | RR 1.03 [0.81, 1.31] | 7 studies · 3075 participants | Moderate Downgraded: inconsistency |
IgE‐mediated food allergy (oral food challenge) by 1 to 2 years Skin care intervention vs standard skin care or no skin care intervention | RR 2.53 [0.99, 6.47] | 1 study · 996 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Slippages (over the intervention period) Skin care intervention vs standard skin care or no skin care intervention | RR 1.42 [0.67, 2.99] | 4 studies · 2538 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Skin infection (over the intervention period) Skin care intervention vs standard skin care or no skin care intervention | RR 1.34 [1.02, 1.77] | 6 studies · 2728 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Stinging/allergic reactions to moisturisers (over the intervention period) Skin care intervention vs standard skin care or no skin care intervention | RR 2.24 [0.67, 7.43] | 4 studies · 343 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Time to onset of eczema Skin care intervention vs standard skin care or no skin care intervention | HR 0.86 [0.65, 1.14] | 9 studies · 3349 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Parent report of immediate reaction to common food allergen (at 2 years) Skin care intervention vs standard skin care or no skin care intervention | RR 1.27 [1, 1.61] | 1 study · 1171 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Allergic sensitisation to a food allergen (at 1 to 2 years) Skin care intervention vs standard skin care or no skin care intervention | RR 0.86 [0.28, 2.69] | 2 studies · 1055 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |