Cochrane · systematic review · CD013387
Diagnostic test accuracy and cost‐effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma
McAleenan, A, Jones, HE, Kernohan, A, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
19
No studies
2
Included studies
NR
No studies 2 · 9.5%Ungraded 0 · 0%Very low 12 · 57.1%Low 5 · 23.8%Moderate 0 · 0%High 2 · 9.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Accuracy of tests for 1p/19q codeletion in people with glioma: assuming FISH is the reference standard
Population: adults with glioma Role: 1p/19q status is used for diagnosis, to inform treatment decisions and to give information on prognosis (survival) Index tests: any test Threshold for index tests: any threshold Reference standards: FISH Studies: cross‐sectional studies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Test | no estimate extracted | NR | No studies |
CISH | no estimate extracted | 1 study · 38 participants | High |
PCR‐based LOH | no estimate extracted | 15 studies · 915 participants | Low |
Real‐time PCR | no estimate extracted | 2 studies · 40 participants | Very low |
MLPA | no estimate extracted | 2 studies · 33 participants | Very low |
CGH | no estimate extracted | 4 studies · 75 participants | Low |
aCGH | no estimate extracted | 3 studies · 39 participants | Very low |
SNP array | no estimate extracted | 6 studies · 111 participants | Very low |
NGS | no estimate extracted | 6 studies · 243 participants | Low |
MS | no estimate extracted | 1 study · 10 participants | Very low |
NanoString | no estimate extracted | 1 study · 16 participants | Very low |
Accuracy of tests for 1p/19q codeletion in people with glioma: assuming PCR‐based LOH is the reference standard
Population: adults with glioma Role: 1p/19q status is used for diagnosis, to inform treatment decisions and to give information on prognosis (survival) Index tests: any test Threshold for index tests: any threshold Reference standards: PCR‐based LOH Studies: cross‐sectional studies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Test | no estimate extracted | NR | No studies |
FISH | no estimate extracted | 15 studies · 915 participants | Low |
Real‐time PCR | no estimate extracted | 1 study · 10 participants | Very low |
MLPA | no estimate extracted | 1 study · 18 participants | Very low |
CGH | no estimate extracted | 6 studies · 151 participants | Low |
aCGH | no estimate extracted | 4 studies · 57 participants | High |
SNP array | no estimate extracted | 2 studies · 33 participants | Very low |
NGS | no estimate extracted | 1 study · 49 participants | Very low |
MS | no estimate extracted | 1 study · 50 participants | Very low |
G‐banding | no estimate extracted | 1 study · 21 participants | Very low |