Cochrane · systematic review · CD012774
Fecal transplantation for treatment of inflammatory bowel disease
Imdad, A, Pandit, NG, Zaman, M, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
20
current version
GRADE rated
13
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 7 · 35%Very low 10 · 50%Low 3 · 15%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyFecal microbiota transplantation compared to control for induction of remission in ulcerative colitis
Population: people with active UC
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Induction of clinical remission in UC at longest Fecal microbiota transplantation vs control | RR 1.79 [1.13, 2.84] | 10 studies · 468 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Serious adverse events with use of FMT for induction of remission in UC (RR > 1 favors control) Fecal microbiota transplantation vs control | RR 1.77 [0.88, 3.55] | 10 studies · 468 participants | Very low Downgraded: risk of bias, imprecision |
Any adverse events with use of FMT for induction of remission in UC (RR > 1 favors control) Fecal microbiota transplantation vs control | RR 0.99 [0.85, 1.16] | 9 studies · 417 participants | Low Downgraded: risk of bias, imprecision |
Induction of endoscopic remission in UC at longest Fecal microbiota transplantation vs control | RR 1.45 [0.64, 3.29] | 5 studies · 285 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Quality‐of‐life scores: IBDQ with use of FMT for induction of remission in UC (MD > 0 favors FMT) Fecal microbiota transplantation vs control | no estimate extracted | 3 studies · 131 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Fecal microbiota transplantation compared to control for maintenance of remission in ulcerative colitis
Population: people with UC in remission
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maintenance of clinical remission in UC (RR > 1 favors intervention) Fecal microbiota transplantation vs control | RR 2.97 [0.26, 34.42] | 2 studies · 71 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Serious adverse events with use of FMT for maintenance of remission in UC (RR > 1 favors control) Fecal microbiota transplantation vs control | no estimate extracted | 2 studies · 71 participants | Very low Downgraded: risk of bias, imprecision |
Any adverse events with use of FMT for maintenance of remission in UC (RR > 1 favors the control) Fecal microbiota transplantation vs control | RR 1.16 [0.85, 1.59] | 2 studies · 71 participants | Very low Downgraded: risk of bias, imprecision |
Maintenance of endoscopic remission in UC (RR > 1 favors FMT) Fecal microbiota transplantation vs control | RR 3.28 [0.73, 14.74] | 2 studies · 71 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Quality‐of‐life scores with use of FMT for maintenance of remission in UC Fecal microbiota transplantation vs control | no estimate extracted | 1 study · 10 participants | Very low Downgraded: risk of bias, imprecision |
Fecal microbiota transplantation compared to control for induction of remission in Crohn disease
Population: people with active CD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Induction of clinical remission in CD Fecal microbiota transplantation vs control | no estimate extracted | 0 studies · 0 participants | Ungraded |
Serious adverse events with use of FMT for induction of remission in CD Fecal microbiota transplantation vs control | no estimate extracted | 0 studies · 0 participants | Ungraded |
Any adverse events with use of FMT for induction of remission in CD Fecal microbiota transplantation vs control | no estimate extracted | 0 studies · 0 participants | Ungraded |
Induction of endoscopic remission in CD Fecal microbiota transplantation vs control | no estimate extracted | 0 studies · 0 participants | Ungraded |
Quality‐of‐life scores with use of FMT for induction of remission in CD Fecal microbiota transplantation vs control | no estimate extracted | 0 studies · 0 participants | Ungraded |
Fecal microbiota transplantation compared to control for maintenance of remission in Crohn disease
Population: people with CD in remission
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maintenance of remission in CD Fecal microbiota transplantation vs control | RR 1.21 [0.36, 4.14] | 1 study · 21 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events with use of FMT for maintenance of remission in CD Fecal microbiota transplantation vs control | no estimate extracted | 1 study · 1 participants | Very low Downgraded: risk of bias, imprecision |
Any adverse events with use of FMT for maintenance of remission in CD Fecal microbiota transplantation vs control | no estimate extracted | 1 study · 1 participants | Very low Downgraded: risk of bias, imprecision |
Maintenance of endoscopic remission in CD Fecal microbiota transplantation vs control | no estimate extracted | 0 studies · 0 participants | Ungraded |
Quality‐of‐life scoreswith use of FMT for maintenance of remission in CD Fecal microbiota transplantation vs control | no estimate extracted | 0 studies · 0 participants | Ungraded |
Fecal microbiota transplantation compared to control for treatment of ulcerative colitis
Population: Participants with active ulcerative colitis inadequately controlled with medication
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical remission at 8 weeks Fecal microbiota transplantation vs control | RR 2.03 [1.07, 3.86] | 4 studies · 277 participants | Low Downgraded: inconsistency |
Serious adverse events Fecal microbiota transplantation vs control | RR 1.4 [0.55, 3.58] | 4 studies · 277 participants | Low Downgraded: imprecision, inconsistency |
Adverse events Fecal microbiota transplantation vs control | RR 1.03 [0.81, 1.31] | 2 studies · 129 participants | Moderate Downgraded: imprecision, inconsistency |
Clinical response at 8 weeks Fecal microbiota transplantation vs control | RR 1.7 [0.98, 2.95] | 4 studies · 277 participants | Low Downgraded: imprecision, inconsistency |
Endoscopic remission at 8 weeks Fecal microbiota transplantation vs control | RR 2.96 [1.6, 5.48] | 3 studies · 229 participants | Moderate Downgraded: imprecision, inconsistency |
Clinical relapse at 12 weeks Fecal microbiota transplantation vs control | RR 0.28 [0.02, 4.98] | 1 study · 17 participants | Low Downgraded: imprecision, inconsistency |
Endoscopic response at 8 weeks Fecal microbiota transplantation vs control | RR 1.36 [0.26, 7.02] | 2 studies · 129 participants | Very low Downgraded: imprecision, inconsistency |