Cochrane · systematic review · CD012661
Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia
Richter, B, Hemmingsen, B, Metzendorf, MI, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Metabolic and Endocrine DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
43
current version
GRADE rated
43
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 29 · 67.4%Moderate 14 · 32.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings: overall prognosis of people with intermediate hyperglycaemia for developing T2DM
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
1 | no estimate extracted | NR | Moderate Downgraded: imprecision |
2 | no estimate extracted | 2 participants | Moderate Downgraded: imprecision |
3 | no estimate extracted | 17 participants | Moderate Downgraded: imprecision |
4 | no estimate extracted | 17 participants | Moderate Downgraded: imprecision |
5 | no estimate extracted | 18 participants | Moderate Downgraded: imprecision |
6 | no estimate extracted | 22 participants | Moderate Downgraded: imprecision |
7 | no estimate extracted | 18 participants | Moderate Downgraded: imprecision |
8 | no estimate extracted | 34 participants | Moderate Downgraded: imprecision |
9 | no estimate extracted | 38 participants | Moderate Downgraded: imprecision |
10 | no estimate extracted | 23 participants | Moderate Downgraded: imprecision |
11 | no estimate extracted | NR | Moderate Downgraded: imprecision |
12 | no estimate extracted | 31 participants | Moderate Downgraded: imprecision |
15 | no estimate extracted | NR | Moderate Downgraded: imprecision |
20 | no estimate extracted | NR | Moderate Downgraded: imprecision |
Summary of findings: risk of intermediate hyperglycaemia (IFG5.6 mmol/L definition) versus normoglycaemia for developing T2DM
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
HR: 4 IRR: 6 OR: 10 Summary of findings: risk of intermediate hyperglycaemia (IFG5.6 mmol/L definition) vs normoglycaemia | no estimate extracted | 2385 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 3 IRR: 3 OR: 9 Summary of findings: risk of intermediate hyperglycaemia (IFG5.6 mmol/L definition) vs normoglycaemia | no estimate extracted | 5685 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 0 IRR: 0 OR: 1 Summary of findings: risk of intermediate hyperglycaemia (IFG5.6 mmol/L definition) vs normoglycaemia | no estimate extracted | 0 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 1 IRR: 1 OR: 1 Summary of findings: risk of intermediate hyperglycaemia (IFG5.6 mmol/L definition) vs normoglycaemia | no estimate extracted | 947 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 8 IRR: 10 OR: 21 Summary of findings: risk of intermediate hyperglycaemia (IFG5.6 mmol/L definition) vs normoglycaemia | no estimate extracted | 9017 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Summary of findings: risk of intermediate hyperglycaemia (IFG6.1 mmol/L definition) versus normoglycaemia for developing T2DM
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
HR: 5 IRR: 2 OR: 7 Summary of findings: risk of intermediate hyperglycaemia (IFG6.1 mmol/L definition) vs normoglycaemia | no estimate extracted | 1054 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 4 IRR: 4 OR: 7 Summary of findings: risk of intermediate hyperglycaemia (IFG6.1 mmol/L definition) vs normoglycaemia | no estimate extracted | 1736 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 0 IRR: 0 OR: 1 Summary of findings: risk of intermediate hyperglycaemia (IFG6.1 mmol/L definition) vs normoglycaemia | no estimate extracted | 0 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 0 IRR: 0 OR: 0 Summary of findings: risk of intermediate hyperglycaemia (IFG6.1 mmol/L definition) vs normoglycaemia | no estimate extracted | 0 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 9 IRR: 6 OR: 15 Summary of findings: risk of intermediate hyperglycaemia (IFG6.1 mmol/L definition) vs normoglycaemia | no estimate extracted | 2818 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Summary of findings: risk of intermediate hyperglycaemia (IGT definition) versus normoglycaemia for developing T2DM
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
HR: 3 IRR: 5 OR: 6 Summary of findings: risk of intermediate hyperglycaemia (IGT definition) vs normoglycaemia | no estimate extracted | 1780 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 2 IRR: 5 OR: 11 Summary of findings: risk of intermediate hyperglycaemia (IGT definition) vs normoglycaemia | no estimate extracted | 2230 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 0 IRR: 0 OR: 2 Summary of findings: risk of intermediate hyperglycaemia (IGT definition) vs normoglycaemia | no estimate extracted | 0 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
IRR: 2 OR: 1 HR: 0 Summary of findings: risk of intermediate hyperglycaemia (IGT definition) vs normoglycaemia | no estimate extracted | 1087 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 5 IRR: 12 OR: 20 Summary of findings: risk of intermediate hyperglycaemia (IGT definition) vs normoglycaemia | no estimate extracted | 4010 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Summary of findings: risk of intermediate hyperglycaemia (combined IFG and IGT definition) versus normoglycaemia for developing T2DM
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
HR: 3 IRR: 4 OR: 3 Summary of findings: risk of intermediate hyperglycaemia (combined IFG and IGT definition) vs normoglycaemia | no estimate extracted | 461 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 1 IRR: 4 OR: 6 Summary of findings: risk of intermediate hyperglycaemia (combined IFG and IGT definition) vs normoglycaemia | no estimate extracted | 221 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 0 IRR: 0 OR: 0 Summary of findings: risk of intermediate hyperglycaemia (combined IFG and IGT definition) vs normoglycaemia | no estimate extracted | 0 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 1 IRR: 1 OR: 0 Summary of findings: risk of intermediate hyperglycaemia (combined IFG and IGT definition) vs normoglycaemia | no estimate extracted | 356 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 5 IRR: 9 OR: 9 Summary of findings: risk of intermediate hyperglycaemia (combined IFG and IGT definition) vs normoglycaemia | no estimate extracted | 1038 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Summary of findings: risk of intermediate hyperglycaemia (HbA1c5.7 definition) versus normoglycaemia for developing T2DM
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
HR: 3 IRR: 1 OR: 1 Summary of findings: risk of intermediate hyperglycaemia (HbA1c5.7 definition) vs normoglycaemia | no estimate extracted | 3196 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 1 IRR: 0 OR: 2 Summary of findings: risk of intermediate hyperglycaemia (HbA1c5.7 definition) vs normoglycaemia | no estimate extracted | 2027 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 0 IRR: 0 OR: 0 Summary of findings: risk of intermediate hyperglycaemia (HbA1c5.7 definition) vs normoglycaemia | no estimate extracted | 0 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HR: 4 IRR: 1 OR: 3 Summary of findings: risk of intermediate hyperglycaemia (HbA1c5.7 definition) vs normoglycaemia | no estimate extracted | 5223 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Summary of findings: risk of intermediate hyperglycaemia (HbA1c6.0 definition) versus normoglycaemia for developing T2DM
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
HR: 2 IRR: 0 OR: 1 Summary of findings: risk of intermediate hyperglycaemia (HbA1c6.0 definition) vs normoglycaemia | no estimate extracted | 1040 participants | Low Downgraded: risk of bias, imprecision |
HR: 4 IRR: 0 OR: 1 Summary of findings: risk of intermediate hyperglycaemia (HbA1c6.0 definition) vs normoglycaemia | no estimate extracted | 3492 participants | Low Downgraded: risk of bias, imprecision |
HR: 0 IRR: 0 OR: 0 Summary of findings: risk of intermediate hyperglycaemia (HbA1c6.0 definition) vs normoglycaemia | no estimate extracted | 0 participants | Low Downgraded: risk of bias, imprecision |
IRR: 0 OR: 1 HR: 0 Summary of findings: risk of intermediate hyperglycaemia (HbA1c6.0 definition) vs normoglycaemia | no estimate extracted | 0 participants | Low Downgraded: risk of bias, imprecision |
HR: 6 IRR: 0 OR: 3 Summary of findings: risk of intermediate hyperglycaemia (HbA1c6.0 definition) vs normoglycaemia | no estimate extracted | 4532 participants | Low Downgraded: risk of bias, imprecision |