Cochrane · systematic review · CD012643
Interim PET‐results for prognosis in adults with Hodgkin lymphoma: a systematic review and meta‐analysis of prognostic factor studies
Aldin, A, Umlauff, L, Estcourt, LJ, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
4
No studies
1
Included studies
NR
No studies 1 · 20%Ungraded 0 · 0%Very low 1 · 20%Low 1 · 20%Moderate 2 · 40%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyComparison of interim PET‐negative and interim PET‐positive individuals with Hodgkin Lymphoma
Population: Individuals with Hodgkin lymphoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival | HR 5.09 [2.64, 9.81] | 9 studies · 1802 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Progression‐free survival | HR 4.9 [3.47, 6.9] | 14 studies · 2079 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse events associated with PET ‐ not reported | no estimate extracted | NR | No studies |
Overall survival (adjusted effect estimate) | no estimate extracted | 2 studies · 843 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Progression‐free survival (adjusted effect estimate) | no estimate extracted | 4 studies · 996 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Comparison of interim PET‐negative and interim PET‐positive individuals with Hodgkin Lymphoma
Population: Individuals with Hodgkin lymphoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival | HR 5.09 [2.64, 9.81] | 9 studies · 1802 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Progression‐free survival | HR 4.9 [3.47, 6.9] | 14 studies · 2079 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse events associated with PET ‐ not reported | no estimate extracted | NR | No studies |
Overall survival (adjusted effect estimate) | no estimate extracted | 2 studies · 843 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Progression‐free survival (adjusted effect estimate) | no estimate extracted | 4 studies · 996 participants | Low Downgraded: risk of bias, imprecision, inconsistency |