Cochrane · systematic review · CD012610
Lipid‐based nutrient supplements for maternal, birth, and infant developmental outcomes
Das, JK, Hoodbhoy, Z, Salam, RA, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Developmental, Psychosocial and Learning ProblemsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
13
No studies
1
Included studies
NR
No studies 1 · 7.1%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 13 · 92.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings: lipid‐based nutrient supplements (LNS) versus iron folic acid (IFA)
Population: pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Gestational weight gain per week (from < 20 weeks gestation till the time of delivery) Summary of findings: lipid‐based nutrient supplements (LNS) vs iron folic acid (IFA) | no estimate extracted | 2 studies · 3539 participants | Moderate Downgraded: risk of bias |
Maternal anaemia at term or near term (haemoglobin (Hb) less than 110 g/L) Summary of findings: lipid‐based nutrient supplements (LNS) vs iron folic acid (IFA) | RR 2.35 [1.67, 3.3] | 1 study · 536 participants | Moderate Downgraded: risk of bias |
Maternal mortality (measured at six weeks postpartum) Summary of findings: lipid‐based nutrient supplements (LNS) vs iron folic acid (IFA) | RR 0.53 [0.12, 2.41] | 3 studies · 5628 participants | Moderate Downgraded: risk of bias |
Low birth weight (< 2500 g) Summary of findings: lipid‐based nutrient supplements (LNS) vs iron folic acid (IFA) | RR 0.87 [0.72, 1.05] | 3 studies · 4826 participants | Moderate Downgraded: risk of bias |
Length at birth (in cm) Summary of findings: lipid‐based nutrient supplements (LNS) vs iron folic acid (IFA) | no estimate extracted | 3 studies · 4986 participants | Moderate Downgraded: risk of bias |
Small‐for‐gestational age Summary of findings: lipid‐based nutrient supplements (LNS) vs iron folic acid (IFA) | RR 0.94 [0.89, 0.99] | 3 studies · 4823 participants | Moderate Downgraded: risk of bias |
Preterm births (births before 37 weeks of gestation) Summary of findings: lipid‐based nutrient supplements (LNS) vs iron folic acid (IFA) | RR 0.94 [0.8, 1.11] | 3 studies · 5924 participants | Moderate Downgraded: risk of bias |
Summary of findings: lipid‐based nutrient supplements (LNS) versus multiple micronutrients (MMN)
Population: pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Gestational weight gain per week (from < 20 weeks gestation till the time of delivery) Summary of findings: lipid‐based nutrient supplements (LNS) vs multiple micronutrients (MMN) | no estimate extracted | 1 study · 682 participants | Moderate Downgraded: risk of bias |
Maternal anaemia at term or near term (haemoglobin (Hb) less than 110 g/L) Summary of findings: lipid‐based nutrient supplements (LNS) vs multiple micronutrients (MMN) | RR 1.4 [1.07, 1.82] | 1 study · 557 participants | Moderate Downgraded: risk of bias |
Maternal mortality (measured at six weeks postpartum) Summary of findings: lipid‐based nutrient supplements (LNS) vs multiple micronutrients (MMN) | no estimate extracted | NR | No studies |
Low birth weight (< 2500 g) Summary of findings: lipid‐based nutrient supplements (LNS) vs multiple micronutrients (MMN) | RR 0.92 [0.74, 1.14] | 3 studies · 2404 participants | Moderate Downgraded: risk of bias |
Length at birth (in cm) Summary of findings: lipid‐based nutrient supplements (LNS) vs multiple micronutrients (MMN) | no estimate extracted | 3 studies · 2567 participants | Moderate Downgraded: risk of bias |
Small‐for‐gestational age Summary of findings: lipid‐based nutrient supplements (LNS) vs multiple micronutrients (MMN) | RR 0.95 [0.84, 1.07] | 3 studies · 2393 participants | Moderate Downgraded: risk of bias |
Preterm births (births before 37 weeks of gestation) Summary of findings: lipid‐based nutrient supplements (LNS) vs multiple micronutrients (MMN) | RR 1.15 [0.93, 1.42] | 3 studies · 2393 participants | Moderate Downgraded: risk of bias |