Cochrane · systematic review · CD012513

Interventions for weight reduction in obesity to improve survival in women with endometrial cancer

Agnew, H, Kitson, S, Crosbie, EJ · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library

Gynaecological, Neuro-oncology and Orphan Cancer2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 42.9%Low 4 · 57.1%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Summary of findings table ‐ Lifestyle intervention versus usual care compared to placebo for weight reduction in obesity to improve survival in women with endometrial cancer

Population: weight reduction in obesity to improve survival in women with endometrial cancer

CD012513.PUB3 (current) · 7 questions

Outcome	Effect	Evidence	Status / GRADE
Overall survival (12 months) Summary of findings table ‐ Lifestyle intervention vs usual care compared to placebo	no estimate extracted	2 studies · 2 participants	Low Downgraded: risk of bias, imprecision
Overall survival (24 months) Summary of findings table ‐ Lifestyle intervention vs usual care compared to placebo	RR 0.23 [0.01, 4.55]	1 study · 37 participants	Very low Downgraded: risk of bias, imprecision, indirectness
Adverse events – musculoskeletal Summary of findings table ‐ Lifestyle intervention vs usual care compared to placebo	RR 19.03 [1.17, 310.52]	8 studies · 315 participants	Very low Downgraded: risk of bias, imprecision
Cancer‐specific survival (6 months) Summary of findings table ‐ Lifestyle intervention vs usual care compared to placebo	no estimate extracted	5 studies · 5 participants	Low Downgraded: risk of bias, imprecision
Weight loss (6 months) Summary of findings table ‐ Lifestyle intervention vs usual care compared to placebo	no estimate extracted	5 studies · 209 participants	Low Downgraded: risk of bias, imprecision
Cardiovascular and metabolic event frequency (6 months) Summary of findings table ‐ Lifestyle intervention vs usual care compared to placebo	RR 3.47 [0.15, 82.21]	5 studies · 211 participants	Low Downgraded: risk of bias, imprecision
Quality of life: FACT‐G (12 months) Summary of findings table ‐ Lifestyle intervention vs usual care compared to placebo	no estimate extracted	2 studies · 89 participants	Very low Downgraded: risk of bias

Lifestyle intervention versus usual care compared to placebo for weight reduction in obesity to improve survival in women with endometrial cancer

Population: weight reduction in obesity to improve survival in women with endometrial cancer

CD012513.PUB2 · 7 questions

Outcome	Effect	Evidence	Status / GRADE
Overall survival (24 months) (Number of deaths from any cause) Lifestyle intervention vs usual care compared to placebo	RR 0.23 [0.01, 4.55]	1 study · 37 participants	Very low Downgraded: risk of bias
Adverse events‐musculoskeletal (Number of musculoskeletal adverse events reported) Lifestyle intervention vs usual care compared to placebo	RR 19.03 [1.17, 310.52]	2 studies · 91 participants	Low Downgraded: risk of bias
Recurrence‐free survival (24 months) (Number of cases of disease recurrence or death) Lifestyle intervention vs usual care compared to placebo	no estimate extracted	NR	No studies
Cancer‐specific survival (24 months) (Number of cancer‐related deaths) Lifestyle intervention vs usual care compared to placebo	no estimate extracted	1 study · 37 participants	Very low Downgraded: risk of bias
Weight loss (12 months) (Change in weight from baseline in kg; positive values = weight gain, negative values = weight lost) Lifestyle intervention vs usual care compared to placebo	no estimate extracted	2 studies · 91 participants	Very low Downgraded: risk of bias
Cardiovascular and metabolic event frequency (12 months) (Number of strokes, myocardial infarctions and hospitalisations for heart failure) Lifestyle intervention vs usual care compared to placebo	no estimate extracted	2 studies · 93 participants	Very low Downgraded: risk of bias
Quality of life FACT‐G (12 months) (Change in QOL on FACT‐G questionnaire from baseline; positive values = improved QOL, negative values = worsening QOL) Lifestyle intervention vs usual care compared to placebo	no estimate extracted	2 studies · 89 participants	Very low Downgraded: risk of bias, imprecision, indirectness