Cochrane · systematic review · CD012282
Fluvastatin for lowering lipids
Adams, SP, Sekhon, SS, Tsang, M, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
HypertensionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
19
current version
GRADE rated
13
No studies
3
Included studies
NR
No studies 3 · 15.8%Ungraded 3 · 15.8%Very low 1 · 5.3%Low 0 · 0%Moderate 0 · 0%High 12 · 63.2%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: participants with normal or abnormal lipid profiles
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
LDL‐cholesterol fluvastatin 10 mg/day | no estimate extracted | 6 studies · 595 participants | High |
LDL‐cholesterol fluvastatin 20 mg/day | no estimate extracted | 55 studies · 9010 participants | High |
LDL‐cholesterol fluvastatin 40 mg/day | no estimate extracted | 57 studies · 3658 participants | High |
LDL‐cholesterol fluvastatin 80 mg/day | no estimate extracted | 32 studies · 4928 participants | High |
CI: Confidence interval | no estimate extracted | NR | No studies |
Mean baseline values. | no estimate extracted | 1 participants | Ungraded |
Comparison
Population: participants with normal or abnormal lipid profiles
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total cholesterol fluvastatin 10 mg/day | no estimate extracted | 4 studies · 287 participants | High |
Total cholesterol fluvastatin 20 mg/day | no estimate extracted | 50 studies · 6309 participants | High |
Total cholesterol fluvastatin 40 mg/day | no estimate extracted | 55 studies · 2966 participants | High |
Total cholesterol fluvastatin 80 mg/day | no estimate extracted | 27 studies · 3943 participants | High |
CI: Confidence interval | no estimate extracted | NR | No studies |
Mean baseline values. | no estimate extracted | 1 participants | Ungraded |
Comparison
Population: participants with normal or abnormal lipid profiles
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Triglycerides fluvastatin 10 mg/day | no estimate extracted | 3 studies · 259 participants | High |
Triglycerides fluvastatin 20 mg/day | no estimate extracted | 39 studies · 7510 participants | High |
Triglycerides fluvastatin 40 mg/day | no estimate extracted | 48 studies · 2646 participants | High |
Triglycerides fluvastatin 80 mg/day | no estimate extracted | 23 studies · 3623 participants | High |
CI: Confidence interval | no estimate extracted | NR | No studies |
Mean baseline values. | no estimate extracted | 1 participants | Ungraded |
Comparison
Population: participants with normal or abnormal lipid profiles
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
WDAEs within 3‐12 weeks | RR 1.52 [0.94, 2.45] | 16 studies · 3023 participants | Very low Downgraded: risk of bias, imprecision |