Cochrane · systematic review · CD012129

Aspirin (single dose) for perineal pain in the early postpartum period

Shepherd, E, Grivell, RM · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library

Pregnancy and Childbirth2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 2 · 40%Very low 2 · 40%Low 1 · 20%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Aspirin compared with placebo for perineal pain in the early postpartum period

Population: women with perineal pain in the early postpartum period

CD012129.PUB3 (current) · 5 questions

Outcome	Effect	Evidence	Status / GRADE
Adequate pain relief as reported by the woman (4 to 8 hours) Aspirin vs placebo	RR 2.03 [1.69, 2.42]	13 studies · 1001 participants	Low Downgraded: risk of bias
Need for additional pain relief (4 to 8 hours) Aspirin vs placebo	RR 0.25 [0.17, 0.37]	10 studies · 744 participants	Very low Downgraded: risk of bias, publication bias
Maternal adverse effects (4 to 8 hours) Aspirin vs placebo	RR 1.08 [0.57, 2.06]	14 studies · 1067 participants	Very low Downgraded: risk of bias, imprecision
Neonatal adverse effects Aspirin vs placebo	no estimate extracted	0 studies · 0 participants	Ungraded
Perineal pain at six weeks postpartum Aspirin vs placebo	no estimate extracted	0 studies · 0 participants	Ungraded

Aspirin compared with placebo for perineal pain in the early postpartum period

Population: women with perineal pain in the early postpartum period

CD012129.PUB2 · 5 questions

Outcome	Effect	Evidence	Status / GRADE
Adequate pain relief as reported by the woman (4 to 8 hours) Aspirin vs placebo	RR 2.03 [1.69, 2.42]	13 studies · 1001 participants	Low Downgraded: risk of bias
Need for additional pain relief (4 to 8 hours) Aspirin vs placebo	RR 0.25 [0.17, 0.37]	10 studies · 744 participants	Very low Downgraded: risk of bias
Maternal adverse effects (4 to 8 hours) Aspirin vs placebo	RR 1.08 [0.57, 2.06]	14 studies · 1067 participants	Very low Downgraded: risk of bias
Neonatal adverse effects Aspirin vs placebo	no estimate extracted	0 studies · 0 participants	Ungraded
Perineal pain at six weeks postpartum Aspirin vs placebo	no estimate extracted	0 studies · 0 participants	Ungraded