Cochrane · systematic review · CD012024
Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy
Dodd, JM, Grivell, RM, OBrien, CM, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
10
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 16.7%Very low 0 · 0%Low 5 · 41.7%Moderate 4 · 33.3%High 1 · 8.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyIntramuscular (IM) progesterone compared to no treatment or placebo for preventing spontaneous preterm birth in women with a multiple pregnancy
Population: Women with a multiple pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Perinatal death Intramuscular (IM) progesterone vs no treatment or placebo | RR 1.45 [0.6, 3.51] | 6 studies · 3089 participants | Low Downgraded: imprecision, inconsistency |
Preterm birth less than 34 weeks Intramuscular (IM) progesterone vs no treatment or placebo | RR 1.54 [1.06, 2.26] | 2 studies · 399 participants | Low Downgraded: risk of bias, imprecision |
Major neurodevelopmental disability at childhood Intramuscular (IM) progesterone vs no treatment or placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Infant birthweight less than 2500 g Intramuscular (IM) progesterone vs no treatment or placebo | RR 0.99 [0.9, 1.08] | 5 studies · 4071 participants | Moderate Downgraded: inconsistency |
Preterm birth less than 28 weeks Intramuscular (IM) progesterone vs no treatment or placebo | RR 1.08 [0.75, 1.55] | 5 studies · 1920 participants | Moderate Downgraded: imprecision, inconsistency |
Preterm birth less than 37 weeks Intramuscular (IM) progesterone vs no treatment or placebo | RR 1.05 [0.98, 1.13] | 5 studies · 2010 participants | High |
Vaginal progesterone compared to no treatment or placebo for preventing spontaneous preterm birth in women with a multiple pregnancy
Population: Women with a multiple pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Perinatal death Vaginal progesterone vs no treatment or placebo | RR 1.23 [0.74, 2.06] | 3 studies · 2287 participants | Low Downgraded: imprecision |
Preterm birth less than 34 weeks Vaginal progesterone vs no treatment or placebo | RR 0.9 [0.66, 1.23] | 5 studies · 1503 participants | Low Downgraded: imprecision |
Major neurodevelopmental disability at childhood Vaginal progesterone vs no treatment or placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Infant birthweight less than 2500 g Vaginal progesterone vs no treatment or placebo | RR 0.95 [0.84, 1.07] | 3 studies · 2640 participants | Moderate Downgraded: inconsistency |
Preterm birth less than 37 weeks Vaginal progesterone vs no treatment or placebo | RR 0.97 [0.89, 1.06] | 6 studies · 1597 participants | Moderate Downgraded: imprecision |
Preterm birth less than 28 weeks Vaginal progesterone vs no treatment or placebo | RR 1.53 [0.79, 2.97] | 3 studies · 1345 participants | Low Downgraded: imprecision |
Intramuscular (IM) progesterone compared to no treatment or placebo for preventing spontaneous preterm birth in women with a multiple pregnancy
Population: Women with a multiple pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Perinatal death Intramuscular (IM) progesterone vs no treatment or placebo | RR 1.45 [0.6, 3.51] | 6 studies · 3089 participants | Low Downgraded: imprecision, inconsistency |
Preterm birth less than 34 weeks Intramuscular (IM) progesterone vs no treatment or placebo | RR 1.54 [1.06, 2.26] | 2 studies · 399 participants | Low Downgraded: risk of bias, imprecision |
Major neurodevelopmental disability at childhood Intramuscular (IM) progesterone vs no treatment or placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Infant birthweight less than 2500 g Intramuscular (IM) progesterone vs no treatment or placebo | RR 0.99 [0.9, 1.08] | 5 studies · 4071 participants | Moderate Downgraded: inconsistency |
Preterm birth less than 28 weeks Intramuscular (IM) progesterone vs no treatment or placebo | RR 1.08 [0.75, 1.55] | 5 studies · 1920 participants | Moderate Downgraded: imprecision, inconsistency |
Preterm birth less than 37 weeks Intramuscular (IM) progesterone vs no treatment or placebo | RR 1.05 [0.98, 1.13] | 5 studies · 2010 participants | High |
Vaginal progesterone compared to no treatment or placebo for preventing spontaneous preterm birth in women with a multiple pregnancy
Population: Women with a multiple pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Perinatal death Vaginal progesterone vs no treatment or placebo | RR 1.23 [0.74, 2.06] | 3 studies · 2287 participants | Low Downgraded: imprecision |
Preterm birth less than 34 weeks Vaginal progesterone vs no treatment or placebo | RR 0.83 [0.63, 1.09] | 6 studies · 1727 participants | Low Downgraded: imprecision |
Major neurodevelopmental disability at childhood Vaginal progesterone vs no treatment or placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Infant birthweight less than 2500 g Vaginal progesterone vs no treatment or placebo | RR 0.95 [0.88, 1.03] | 4 studies · 3079 participants | Moderate |
Preterm birth less than 37 weeks Vaginal progesterone vs no treatment or placebo | RR 0.97 [0.89, 1.06] | 6 studies · 1597 participants | Moderate Downgraded: imprecision |
Preterm birth less than 28 weeks Vaginal progesterone vs no treatment or placebo | RR 1.22 [0.68, 2.21] | 4 studies · 1569 participants | Low Downgraded: imprecision |