Cochrane · systematic review · CD011792
Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP)
Maguire, MJ, Jackson, CF, Marson, AG, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
2
Included studies
NR
No studies 2 · 28.6%Ungraded 0 · 0%Very low 5 · 71.4%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyInterventions for compared with no intervention for preventing Sudden Unexpected Death in Epilepsy (SUDEP)
Population: cases of SUDEP and matched controls (number of deaths due to SUDEP) and consecutive people with epilepsy from a tertiary care teaching hospital in Northern India (change in mean depression and anxiety scores and change in quality of life)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of deaths due to SUDEP: nocturnal supervision compared to no supervision Interventions for vs no intervention | no estimate extracted | 203 participants | Very low Downgraded: risk of bias |
Number of deaths due to SUDEP: additional nocturnal supervision compared to no additional supervision Interventions for vs no intervention | OR 0.76 [0.4, 1.46] | 48 participants | Very low Downgraded: risk of bias |
Number of deaths due to SUDEP: special precautions compared to no special precautions Interventions for vs no intervention | OR 0.41 [0.2, 0.82] | 155 participants | Very low Downgraded: risk of bias |
Number of other deaths (unrelated to SUDEP) Interventions for vs no intervention | no estimate extracted | NR | No studies |
Change in mean depression and anxiety scores Interventions for vs no intervention | no estimate extracted | 222 participants | Very low Downgraded: risk of bias |
Clinically important change in quality of life Interventions for vs no intervention | no estimate extracted | 215 participants | Very low Downgraded: risk of bias |
Number of hospital attendances for seizures Interventions for vs no intervention | no estimate extracted | NR | No studies |
Interventions for compared with no intervention for preventing Sudden Unexpected Death in Epilepsy (SUDEP)
Population: Cases of SUDEP and matched controls
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of deaths due to SUDEP: Nocturnal supervision compared to no supervision Interventions for vs no intervention | OR 0.34 [0.22, 0.53] | 1 study · 468 participants | Very low Downgraded: risk of bias |
Number of deaths due to SUDEP: Special precautions compared to no special precautions Interventions for vs no intervention | OR 0.41 [0.2, 0.82] | 1 study · 331 participants | Very low Downgraded: risk of bias |
Number of other deaths (unrelated to SUDEP) Interventions for vs no intervention | no estimate extracted | NR | No studies |
Change in mean depression and anxiety scores Interventions for vs no intervention | no estimate extracted | NR | No studies |
Clinically important change in quality of life Interventions for vs no intervention | no estimate extracted | NR | No studies |
Number of hospital attendances for seizures Interventions for vs no intervention | no estimate extracted | NR | No studies |