Cochrane · systematic review · CD011624
Different intensities of glycaemic control for women with gestational diabetes mellitus
Hofer, OJ, Martis, R, Alsweiler, J, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
8
No studies
6
Included studies
NR
No studies 6 · 42.9%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 28.6%Moderate 4 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyIntensity of glycaemic control for women with gestational diabetes mellitus: tight glycaemic targets versus less‐tight glycaemic targets (maternal outcomes)
Population: women with gestational diabetes mellitus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Hypertensive disorders of pregnancy (including pre‐eclampsia, pregnancy‐induced hypertension, eclampsia) Intensity of glycaemic control for women with gestational diabetes mellitus: tight glycaemic targets vs less‐tight glycaemic targets (maternal outcomes) | RR 1.16 [0.8, 1.69] | 2 studies · 1491 participants | Low Downgraded: risk of bias, imprecision |
Subsequent development of type 2 diabetes Intensity of glycaemic control for women with gestational diabetes mellitus: tight glycaemic targets vs less‐tight glycaemic targets (maternal outcomes) | no estimate extracted | NR | No studies |
Caesarean section Intensity of glycaemic control for women with gestational diabetes mellitus: tight glycaemic targets vs less‐tight glycaemic targets (maternal outcomes) | 0.98 [0.82, 1.17] | 3 studies · 1662 participants | Moderate Downgraded: risk of bias |
Return to pre‐pregnancy weight Intensity of glycaemic control for women with gestational diabetes mellitus: tight glycaemic targets vs less‐tight glycaemic targets (maternal outcomes) | no estimate extracted | NR | No studies |
Induction of labour Intensity of glycaemic control for women with gestational diabetes mellitus: tight glycaemic targets vs less‐tight glycaemic targets (maternal outcomes) | RR 0.96 [0.78, 1.18] | 1 study · 1096 participants | Moderate Downgraded: imprecision |
Perineal trauma Intensity of glycaemic control for women with gestational diabetes mellitus: tight glycaemic targets vs less‐tight glycaemic targets (maternal outcomes) | no estimate extracted | NR | No studies |
Postnatal depression Intensity of glycaemic control for women with gestational diabetes mellitus: tight glycaemic targets vs less‐tight glycaemic targets (maternal outcomes) | no estimate extracted | NR | No studies |
Intensity of glycaemic control for women with gestational diabetes mellitus: tight glycaemic targets versus less‐tight glycaemic targets (child (as neonate, child, adult) outcomes)
Population: children (as neonate, child, adult) of women with gestational diabetes mellitus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Perinatal (fetal and neonatal) mortality Intensity of glycaemic control for women with gestational diabetes mellitus: tight glycaemic targets vs less‐tight glycaemic targets (child (as neonate, child, adult) outcomes) | no estimate extracted | 2 studies · 1499 participants | Low Downgraded: imprecision |
Large‐for‐gestational‐age Intensity of glycaemic control for women with gestational diabetes mellitus: tight glycaemic targets vs less‐tight glycaemic targets (child (as neonate, child, adult) outcomes) | RR 0.96 [0.72, 1.29] | 3 studies · 1556 participants | Moderate Downgraded: risk of bias |
Composite of mortality or serious morbidity (as defined by trial) Intensity of glycaemic control for women with gestational diabetes mellitus: tight glycaemic targets vs less‐tight glycaemic targets (child (as neonate, child, adult) outcomes) | RR 0.84 [0.55, 1.29] | 3 studies · 1559 participants | Low Downgraded: risk of bias, imprecision |
Neurosensory disability Intensity of glycaemic control for women with gestational diabetes mellitus: tight glycaemic targets vs less‐tight glycaemic targets (child (as neonate, child, adult) outcomes) | no estimate extracted | NR | No studies |
Infant hypoglycaemia Intensity of glycaemic control for women with gestational diabetes mellitus: tight glycaemic targets vs less‐tight glycaemic targets (child (as neonate, child, adult) outcomes) | RR 0.92 [0.72, 1.18] | 3 studies · 1556 participants | Moderate Downgraded: risk of bias |
Adiposity (% fat mass) Intensity of glycaemic control for women with gestational diabetes mellitus: tight glycaemic targets vs less‐tight glycaemic targets (child (as neonate, child, adult) outcomes) | no estimate extracted | 1 study · 60 participants | Low Downgraded: imprecision |
Diabetes Intensity of glycaemic control for women with gestational diabetes mellitus: tight glycaemic targets vs less‐tight glycaemic targets (child (as neonate, child, adult) outcomes) | no estimate extracted | NR | No studies |
Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets versus liberal glycaemic targets (Maternal outcomes)
Population: Women with GDM
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Hypertensive disorders of pregnancy Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs liberal glycaemic targets (Maternal outcomes) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Caesarean section Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs liberal glycaemic targets (Maternal outcomes) | RR 1.35 [0.83, 2.18] | 1 study · 171 participants | Very low Downgraded: risk of bias, imprecision |
Supsequent development of type 2 diabetes Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs liberal glycaemic targets (Maternal outcomes) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Perineal trauma Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs liberal glycaemic targets (Maternal outcomes) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Return to pre‐pregnancy weight Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs liberal glycaemic targets (Maternal outcomes) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Postnatal depression Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs liberal glycaemic targets (Maternal outcomes) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Induction of labour Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs liberal glycaemic targets (Maternal outcomes) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets versus liberal glycaemic targets (Child (as neonate, child, adult) outcomes)
Population: Children (as neonate, child, adult) of women with GDM
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Large‐for‐gestational age ‐ not reported Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs liberal glycaemic targets (Child (as neonate, child, adult) outcomes) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Perinatal mortality ‐ not reported Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs liberal glycaemic targets (Child (as neonate, child, adult) outcomes) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Composite of mortality and serious morbidity ‐ not reported Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs liberal glycaemic targets (Child (as neonate, child, adult) outcomes) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neonatal hypoglycaemia ‐ not reported Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs liberal glycaemic targets (Child (as neonate, child, adult) outcomes) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Adiposity ‐ not reported Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs liberal glycaemic targets (Child (as neonate, child, adult) outcomes) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Diabetes ‐ not reported Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs liberal glycaemic targets (Child (as neonate, child, adult) outcomes) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neurosensory disability ‐ not reported Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs liberal glycaemic targets (Child (as neonate, child, adult) outcomes) | no estimate extracted | 0 studies · 0 participants | Ungraded |