Cochrane · systematic review · CD011564
Vitamin D supplementation for chronic liver diseases in adults
Bjelakovic, M, Nikolova, D, Bjelakovic, G, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 28.6%Very low 5 · 71.4%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyVitamin D compared with placebo or no intervention for chronic liver diseases in adults
Population: people with chronic liver diseases
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Vitamin D vs placebo or no intervention | RR 0.86 [0.51, 1.45] | 27 studies · 1979 participants | Very low Downgraded: risk of bias, imprecision |
Liver‐related mortality Vitamin D vs placebo or no intervention | RR 1.62 [0.08, 34.66] | 1 study · 18 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events Vitamin D vs placebo or no intervention | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision |
Liver‐related morbidity Vitamin D vs placebo or no intervention | no estimate extracted | 0 studies · 0 participants | Ungraded |
Health‐related quality of life Vitamin D vs placebo or no intervention | no estimate extracted | 0 studies · 0 participants | Ungraded |
Non‐serious adverse events Vitamin D vs placebo or no intervention | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision |
Failure of sustained virological response Vitamin D vs placebo or no intervention | RR 0.65 [0.42, 1.01] | 7 studies · 630 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Vitamin D compared to placebo or no intervention for chronic liver diseases in adults
Population: adults with chronic liver diseases.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality at the end of Vitamin D vs placebo or no intervention | OR 0.7 [0.09, 5.38] | 15 studies · 1034 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Liver‐related mortality Vitamin D vs placebo or no intervention | RR 1.62 [0.08, 34.66] | 1 study · 18 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events ‐ hypercalcaemia Vitamin D vs placebo or no intervention | RR 5 [0.25, 100.8] | 1 study · 76 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events ‐ myocardial infarction Vitamin D vs placebo or no intervention | RR 0.75 [0.08, 6.81] | 2 studies · 86 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events ‐ thyroiditis Vitamin D vs placebo or no intervention | RR 0.33 [0.01, 7.91] | 1 study · 68 participants | Very low Downgraded: risk of bias, imprecision |
Failure of sustained virological response Vitamin D vs placebo or no intervention | RR 0.59 [0.28, 1.21] | 5 studies · 422 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Acute cellular rejection in liver transplant recipients Vitamin D vs placebo or no intervention | RR 0.33 [0.04, 2.62] | 1 study · 75 participants | Very low Downgraded: risk of bias, imprecision, indirectness |