Cochrane · systematic review · CD011525
Intermittent preventive treatment for malaria in infants
Esu, EB, Oringanje, C, Meremikwu, MM · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
24
current version
GRADE rated
20
No studies
4
Included studies
NR
No studies 4 · 16.7%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 12.5%Moderate 16 · 66.7%High 1 · 4.2%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version only‘Summary of findings' table 1
Population: children under 12 months of age
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical malaria | Rate ratio 0.78 [0.69, 0.88] | 8 studies · 8774 participants | Moderate Downgraded: imprecision, inconsistency |
Severe malaria | Rate ratio 0.92 [0.47, 1.81] | 2 studies · 1347 participants | Low Downgraded: imprecision, inconsistency |
All‐cause mortality | Risk ratio 0.93 [0.74, 1.15] | 9 studies · 14588 participants | Moderate Downgraded: imprecision, inconsistency |
Hospital admission for any reason | Rate ratio 0.85 [0.78, 0.93] | 7 studies · 7486 participants | Moderate Downgraded: imprecision, inconsistency |
Parasitaemia | Rate ratio 0.66 [0.56, 0.79] | 1 study · 1200 participants | Moderate Downgraded: imprecision, inconsistency |
Anaemia | Rate ratio 0.82 [0.68, 0.98] | 6 studies · 7438 participants | Moderate Downgraded: imprecision, inconsistency |
‘Summary of findings' table 2
Population: malaria in infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical malaria | Rate ratio 0.75 [0.61, 0.94] | 1 study · 547 participants | Moderate Downgraded: imprecision |
Severe malaria | no estimate extracted | NR | No studies |
All‐cause mortality | Risk ratio 1.21 [0.58, 2.55] | 1 study · 684 participants | Moderate Downgraded: imprecision |
Hospital admission for any reason | Rate ratio 0.98 [0.76, 1.27] | 1 study · 684 participants | Moderate Downgraded: imprecision |
Parasitaemia | no estimate extracted | NR | No studies |
Anaemia | Rate ratio 0.77 [0.53, 1.12] | 1 study · 684 participants | Moderate Downgraded: imprecision |
‘Summary of findings' table 3
Population: malaria in infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical malaria | Rate ratio 0.42 [0.33, 0.54] | 1 study · 147 participants | Moderate Downgraded: imprecision |
Severe malaria | Rate ratio 1.29 [0.28, 5.98] | 1 study · 147 participants | Moderate Downgraded: imprecision |
All‐cause mortality | Risk ratio 0.17 [0.01, 4.06] | 1 study · 147 participants | Low Downgraded: imprecision |
Hospital admission for any reason | Rate ratio 1.58 [0.46, 5.42] | 1 study · 147 participants | Low Downgraded: imprecision |
Parasitaemia | no estimate extracted | 1 study · 147 participants | Moderate Downgraded: imprecision |
Anaemia | no estimate extracted | 1 study · 147 participants | Moderate Downgraded: imprecision |
‘Summary of findings' table 4
Population: malaria in infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical malaria | Rate ratio 0.78 [0.62, 0.97] | 1 study · 676 participants | High |
Severe malaria | no estimate extracted | NR | No studies |
All‐cause mortality | Risk ratio 0.83 [0.36, 1.89] | 1 study · 676 participants | Moderate Downgraded: imprecision |
Hospital admission for any reason | Rate ratio 0.92 [0.71, 1.2] | 1 study · 676 participants | Moderate Downgraded: imprecision |
Parasitaemia | no estimate extracted | NR | No studies |
Anaemia | Rate ratio 0.72 [0.49, 1.07] | 1 study · 676 participants | Moderate Downgraded: imprecision |
‘Summary of findings' table 1
Population: children under 12 months of age
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical malaria | Rate ratio 0.79 [0.74, 0.85] | 8 studies · 8774 participants | Moderate Downgraded: imprecision, inconsistency |
Severe malaria | Rate ratio 0.92 [0.47, 1.81] | 2 studies · 1347 participants | Low Downgraded: imprecision, inconsistency |
All‐cause mortality | Risk ratio 0.93 [0.74, 1.15] | 9 studies · 14588 participants | Moderate Downgraded: imprecision, inconsistency |
Hospital admission for any reason | Rate ratio 0.85 [0.78, 0.93] | 7 studies · 7486 participants | Moderate Downgraded: imprecision, inconsistency |
Parasitaemia | Rate ratio 0.66 [0.56, 0.79] | 1 study · 1200 participants | Moderate Downgraded: imprecision, inconsistency |
Anaemia | Rate ratio 0.82 [0.68, 0.98] | 6 studies · 7438 participants | Moderate Downgraded: imprecision, inconsistency |
‘Summary of findings' table 2
Population: malaria in infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical malaria | Rate ratio 0.75 [0.61, 0.94] | 1 study · 547 participants | Moderate Downgraded: imprecision |
Severe malaria | no estimate extracted | NR | No studies |
All‐cause mortality | Risk ratio 1.21 [0.58, 2.55] | 1 study · 684 participants | Moderate Downgraded: imprecision |
Hospital admission for any reason | Rate ratio 0.98 [0.76, 1.27] | 1 study · 684 participants | Moderate Downgraded: imprecision |
Parasitaemia | no estimate extracted | NR | No studies |
Anaemia | Rate ratio 0.77 [0.53, 1.12] | 1 study · 684 participants | Moderate Downgraded: imprecision |
‘Summary of findings' table 3
Population: malaria in infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical malaria | Rate ratio 0.42 [0.33, 0.54] | 1 study · 147 participants | Moderate Downgraded: imprecision |
Severe malaria | Rate ratio 1.29 [0.28, 5.98] | 1 study · 147 participants | Moderate Downgraded: imprecision |
All‐cause mortality | Risk ratio 0.17 [0.01, 4.06] | 1 study · 147 participants | Low Downgraded: imprecision |
Hospital admission for any reason | Rate ratio 1.58 [0.46, 5.42] | 1 study · 147 participants | Low Downgraded: imprecision |
Parasitaemia | no estimate extracted | 1 study · 147 participants | Moderate Downgraded: imprecision |
Anaemia | no estimate extracted | 1 study · 147 participants | Moderate Downgraded: imprecision |
‘Summary of findings' table 4
Population: malaria in infants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical malaria | Rate ratio 0.78 [0.62, 0.97] | 1 study · 676 participants | High |
Severe malaria | no estimate extracted | NR | No studies |
All‐cause mortality | Risk ratio 0.83 [0.36, 1.89] | 1 study · 676 participants | Moderate Downgraded: imprecision |
Hospital admission for any reason | Rate ratio 0.92 [0.71, 1.2] | 1 study · 676 participants | Moderate Downgraded: imprecision |
Parasitaemia | no estimate extracted | NR | No studies |
Anaemia | Rate ratio 0.72 [0.49, 1.07] | 1 study · 676 participants | Moderate Downgraded: imprecision |