Cochrane · systematic review · CD011511
Vitamin D for the management of asthma
Williamson, A, Martineau, AR, Sheikh, A, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 2 · 28.6%High 4 · 57.1%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlySummary of findings table ‐ Vitamin D compared to placebo for the management of asthma
Population: children and adults with predominantly mild to moderate asthma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of participants with one or more exacerbations treated with systemic corticosteroids Summary of findings table ‐ Vitamin D vs placebo | OR 1.04 [0.81, 1.34] | 14 studies · 1778 participants | High |
Proportion of participants with one or more exacerbations requiring emergency department visit or hospitalisation, or both Summary of findings table ‐ Vitamin D vs placebo | OR 0.56 [0.26, 1.21] | 9 studies · 1070 participants | Moderate Downgraded: imprecision |
End‐study asthma control test score Summary of findings table ‐ Vitamin D vs placebo | no estimate extracted | 7 studies · 1271 participants | Moderate Downgraded: inconsistency |
End‐study forced expiratory volume in 1 second, % predicted Summary of findings table ‐ Vitamin D vs placebo | no estimate extracted | 11 studies · 1286 participants | High |
Proportion of participants with one or more serious adverse events due to any cause Summary of findings table ‐ Vitamin D vs placebo | OR 0.89 [0.56, 1.41] | 12 studies · 1556 participants | High |
Proportion of participants with fatal asthma exacerbation Summary of findings table ‐ Vitamin D vs placebo | no estimate extracted | 16 studies · 1976 participants | Low Downgraded: imprecision |
Withdrawals from trial Summary of findings table ‐ Vitamin D vs placebo | OR 1.05 [0.77, 1.43] | 20 studies · 2225 participants | High |
Vitamin D versus placebo for the management of asthma (all studies)
Population: children and adults with predominantly mild to moderate asthma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Rate ratio, exacerbations requiring systemic corticosteroids Vitamin D vs placebo | RR 0.64 [0.46, 0.9] | 3 studies · 680 participants | High |
People with 1 or more exacerbations requiring ED visit or hospitalisation or both. Vitamin D vs placebo | OR 0.39 [0.19, 0.78] | 7 studies · 963 participants | High |
FEV1, % predicted. Vitamin D vs placebo | no estimate extracted | 4 studies · 387 participants | High |
ACT/C‐ACT score. Vitamin D vs placebo | no estimate extracted | 3 studies · 713 participants | High |
People with fatal asthma exacerbation. Vitamin D vs placebo | no estimate extracted | 7 studies · 963 participants | Low Downgraded: imprecision |
People with 1 or more serious adverse event due to any cause. Vitamin D vs placebo | OR 1.01 [0.54, 1.89] | 5 studies · 879 participants | Moderate Downgraded: imprecision |