Cochrane · systematic review · CD011507
Antenatal dietary supplementation with myo‐inositol for preventing gestational diabetes
Motuhifonua, SK, Lin, L, Alsweiler, J, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 7 · 50%Very low 4 · 28.6%Low 3 · 21.4%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyMyo‐inositol for preventing gestational diabetes: maternal outcomes
Population: pregnant women (women with pre‐existing type 1 or type 2 diabetes are NOT included)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Gestational diabetes mellitus | RR 0.53 [0.31, 0.9] | 6 studies · 1140 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Weight gain during pregnancy | no estimate extracted | 4 studies · 831 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Hypertensive disorders of pregnancy | RR 0.34 [0.19, 0.61] | 5 studies · 1052 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Caesarean section | RR 0.91 [0.77, 1.07] | 4 studies · 829 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Perineal trauma | RR 4 [0.45, 35.25] | 1 study · 234 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Postnatal depression | no estimate extracted | 0 studies · 0 participants | Ungraded |
Development of subsequent type 2 diabetes mellitus | no estimate extracted | 0 studies · 0 participants | Ungraded |
Myo‐inositol for preventing gestational diabetes: infant, child and adult outcomes
Population: infants of pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Large‐for‐gestational age | RR 1.4 [0.65, 3.02] | 1 study · 234 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Perinatal mortality (stillbirth and neonatal mortality) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Composite of serious neonatal outcomes | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neonatal hypoglycaemia | RR 3.07 [0.9, 10.52] | 4 studies · 671 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Adiposity | no estimate extracted | 0 studies · 0 participants | Ungraded |
Diabetes | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neurosensory disability | no estimate extracted | 0 studies · 0 participants | Ungraded |
Myo‐inositol for preventing gestational diabetes maternal outcomes (maternal outcomes)
Population: pregnant women (women with pre‐existing type 1 or type 2 diabetes are NOT included)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Gestational diabetes mellitus | RR 0.43 [0.29, 0.64] | 3 studies · 502 participants | Low Downgraded: risk of bias |
Weight gain during pregnancy | no estimate extracted | 2 studies · 411 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Hypertensive disorders of pregnancy | RR 0.43 [0.02, 8.41] | 2 studies · 398 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Caesarean section | RR 0.95 [0.76, 1.19] | 2 studies · 398 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Perineal trauma | no estimate extracted | 0 studies · 0 participants | Ungraded |
Postnatal depression | no estimate extracted | 0 studies · 0 participants | Ungraded |
Type 2 diabetes | no estimate extracted | 0 studies · 0 participants | Ungraded |
Myo‐inositol for preventing gestational diabetes (neonatal, child and adult outcomes)
Population: pregnant women who were at risk of GDM
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Large‐for‐gestational age | no estimate extracted | 0 studies · 0 participants | Ungraded |
Perinatal mortality | no estimate extracted | 0 studies · 0 participants | Ungraded |
Composite of serious neonatal outcomes | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neonatal hypoglycaemia | RR 0.36 [0.01, 8.66] | 2 studies · 398 participants | Very low Downgraded: risk of bias |
Adiposity | no estimate extracted | 0 studies · 0 participants | Ungraded |
Diabetes | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neurosensory disability | no estimate extracted | 0 studies · 0 participants | Ungraded |