Cochrane · systematic review · CD011490
Extended lymph node resection versus standard resection for pancreatic and periampullary adenocarcinoma
Staerkle, RF, Vuille-dit-Bille, RNicolas, Soll, C, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 57.1%Low 1 · 14.3%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Extended compared to standard lymph node resection for pancreatic and periampullary adenocarcinoma
Population: people with pancreatic and periampullary adenocarcinoma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival (1‐year Extended vs standard lymph node resection | HR 0.12 | 7 studies · 823 participants | Very low Downgraded: risk of bias |
Overall survival (3‐year Extended vs standard lymph node resection | HR 0.12 | 7 studies · 823 participants | Very low Downgraded: risk of bias |
Postoperative mortality (duration of Extended vs standard lymph node resection | Peto OR 1.2 [0.51, 2.8] | 7 studies · 843 participants | Low Downgraded: risk of bias |
Operating time Extended vs standard lymph node resection | no estimate extracted | 5 studies · 670 participants | Moderate Downgraded: risk of bias, inconsistency |
Blood loss Extended vs standard lymph node resection | no estimate extracted | 2 studies · 463 participants | Very low Downgraded: risk of bias, inconsistency |
Lymph nodes retrieved Extended vs standard lymph node resection | no estimate extracted | 5 studies · 670 participants | Moderate |
Positive resection margins (R1 + R2) Extended vs standard lymph node resection | RR 0.81 [0.58, 1.13] | 6 studies · 783 participants | Very low Downgraded: risk of bias, inconsistency |