Cochrane · systematic review · CD011475
External beam radiation dose escalation for high grade glioma
Khan, L, Soliman, H, Sahgal, A, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 6 · 66.7%Very low 1 · 11.1%Low 0 · 0%Moderate 1 · 11.1%High 1 · 11.1%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyDaily conventionally fractionated radiotherapy versus no radiotherapy (supportive care alone) for high grade glioma
Population: people with high grade glioma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Daily conventionally fractionated radiotherapy vs no radiotherapy (supportive care alone) | HR 2.01 [1.58, 2.55] | 4 studies · 397 participants | Moderate Downgraded: risk of bias, indirectness |
Adverse effects Daily conventionally fractionated radiotherapy vs no radiotherapy (supportive care alone) | no estimate extracted | 3 studies · 289 participants | Ungraded |
Progression free survival Daily conventionally fractionated radiotherapy vs no radiotherapy (supportive care alone) | no estimate extracted | 1 study · 81 participants | Ungraded |
Quality of life Daily conventionally fractionated radiotherapy vs no radiotherapy (supportive care alone) | no estimate extracted | 1 study · 81 participants | Ungraded |
Hypofractionated radiotherapy versus daily conventionally fractionated radiotherapy for high grade glioma
Population: people with high grade glioma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy | HR 0.95 [0.78, 1.17] | 5 studies · 943 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Adverse effects Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy | no estimate extracted | 4 studies · 848 participants | Ungraded |
Progression free survival Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy | no estimate extracted | 0 studies · 0 participants | Ungraded |
Quality of life Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy | no estimate extracted | 3 studies · 361 participants | Ungraded |
Overall survival for subgroup aged ≥ 60 years glioblastoma Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy | HR 1.16 [0.92, 1.46] | 2 studies · 293 participants | High |
Radiation versus no radiation for high grade glioma
Population: patients with high grade glioma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Radiation vs no radiation | HR 2.01 [1.58, 2.55] | 4 studies · 397 participants | Moderate Downgraded: risk of bias, indirectness |
Adverse effects Radiation vs no radiation | no estimate extracted | 3 studies · 289 participants | Ungraded |
Progression free survival Radiation vs no radiation | no estimate extracted | 1 study · 81 participants | Ungraded |
Quality of life Radiation vs no radiation | no estimate extracted | 1 study · 81 participants | Ungraded |
Hypofractionated radiation versus conventional radiation for high grade glioma
Population: patients with high grade glioma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Hypofractionated radiation vs conventional radiation | HR 0.95 [0.78, 1.17] | 5 studies · 943 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Adverse effects Hypofractionated radiation vs conventional radiation | no estimate extracted | 4 studies · 848 participants | Ungraded |
Progression free survival Hypofractionated radiation vs conventional radiation | no estimate extracted | 0 studies · 0 participants | Ungraded |
Quality of life Hypofractionated radiation vs conventional radiation | no estimate extracted | 3 studies · 361 participants | Ungraded |
Overall survival for subgroup age 60 years and older glioblastoma Hypofractionated radiation vs conventional radiation | HR 1.16 [0.92, 1.46] | 2 studies · 293 participants | High |