Cochrane · systematic review · CD011444
Mefloquine for preventing malaria in pregnant women
González, R, Pons‐Duran, C, Piqueras, M, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
16
current version
GRADE rated
16
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 6.3%Low 1 · 6.3%Moderate 7 · 43.8%High 7 · 43.8%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyMefloquine compared with sulfadoxine‐pyrimethamine for preventing malaria in pregnant women
Population: HIV‐uninfected pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical malaria episodes during pregnancy Mefloquine vs sulfadoxine‐pyrimethamine | IRR 0.83 [0.65, 1.05] | 2 studies · 2 participants | High |
Maternal peripheral parasitaemia at delivery Mefloquine vs sulfadoxine‐pyrimethamine | RR 0.65 [0.48, 0.86] | 2 studies · 5455 participants | High |
Placental malaria Mefloquine vs sulfadoxine‐pyrimethamine | RR 1.04 [0.58, 1.86] | 2 studies · 4668 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Maternal anaemia at delivery Mefloquine vs sulfadoxine‐pyrimethamine | RR 0.84 [0.76, 0.94] | 2 studies · 5469 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Low birth weight Mefloquine vs sulfadoxine‐pyrimethamine | RR 0.95 [0.78, 1.17] | 2 studies · 5641 participants | High |
Stillbirths and abortions Mefloquine vs sulfadoxine‐pyrimethamine | RR 1.2 [0.91, 1.58] | 2 studies · 6219 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
AEs: vomiting Mefloquine vs sulfadoxine‐pyrimethamine | RR 4.76 [4.13, 5.49] | 2 studies · 6272 participants | High |
AEs: dizziness Mefloquine vs sulfadoxine‐pyrimethamine | RR 4.21 [3.36, 5.27] | 2 studies · 6272 participants | Moderate Downgraded: risk of bias, imprecision |
Mefloquine plus cotrimoxazole compared with cotrimoxazole for preventing malaria in pregnant women
Population: HIV‐infected pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical malaria episodes during pregnancy Mefloquine plus cotrimoxazole vs cotrimoxazole | IRR 0.76 [0.33, 1.76] | 1 study · 1 participants | High |
Maternal peripheral parasitaemia at delivery (PCR) Mefloquine plus cotrimoxazole vs cotrimoxazole | RR 0.52 [0.3, 0.93] | 2 studies · 989 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Placental malaria (PCR) Mefloquine plus cotrimoxazole vs cotrimoxazole | RR 0.28 [0.14, 0.57] | 2 studies · 977 participants | Moderate Downgraded: risk of bias |
Maternal anaemia at delivery Mefloquine plus cotrimoxazole vs cotrimoxazole | RR 0.94 [0.73, 1.2] | 2 studies · 1197 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Low birth weight Mefloquine plus cotrimoxazole vs cotrimoxazole | RR 1.2 [0.89, 1.6] | 2 studies · 1220 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Spontaneous abortions and stillbirths Mefloquine plus cotrimoxazole vs cotrimoxazole | RR 1.12 [0.42, 2.98] | 2 studies · 1347 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
AEs: vomiting Mefloquine plus cotrimoxazole vs cotrimoxazole | RR 7.95 [4.79, 13.18] | 1 study · 1055 participants | High |
AEs: dizziness Mefloquine plus cotrimoxazole vs cotrimoxazole | RR 3.94 [2.85, 5.46] | 1 study · 1055 participants | High |
Mefloquine compared with sulfadoxine‐pyrimethamine for preventing malaria in pregnant women
Population: HIV‐uninfected pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical malaria episodes during pregnancy Mefloquine vs sulfadoxine‐pyrimethamine | IRR 0.83 [0.65, 1.05] | 2 studies · 2 participants | High |
Maternal peripheral parasitaemia at delivery Mefloquine vs sulfadoxine‐pyrimethamine | RR 0.65 [0.48, 0.86] | 2 studies · 5455 participants | High |
Placental malaria Mefloquine vs sulfadoxine‐pyrimethamine | RR 1.04 [0.58, 1.86] | 2 studies · 4668 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Maternal anaemia at delivery Mefloquine vs sulfadoxine‐pyrimethamine | RR 0.84 [0.76, 0.94] | 2 studies · 5469 participants | Moderate Downgraded: risk of bias, inconsistency |
Low birth weight Mefloquine vs sulfadoxine‐pyrimethamine | RR 0.95 [0.78, 1.17] | 2 studies · 5641 participants | High |
Stillbirths and abortions Mefloquine vs sulfadoxine‐pyrimethamine | RR 1.2 [0.91, 1.58] | 2 studies · 6219 participants | High |
AEs: vomiting Mefloquine vs sulfadoxine‐pyrimethamine | RR 4.76 [4.13, 5.49] | 2 studies · 6272 participants | High |
AEs: dizziness Mefloquine vs sulfadoxine‐pyrimethamine | RR 4.21 [3.36, 5.27] | 2 studies · 6272 participants | High |
Mefloquine plus cotrimoxazole compared with cotrimoxazole for preventing malaria in pregnant women
Population: HIV‐infected pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical malaria episodes during pregnancy Mefloquine plus cotrimoxazole vs cotrimoxazole | IRR 0.76 [0.33, 1.76] | 1 study · 1 participants | High |
Maternal peripheral parasitaemia at delivery (PCR) Mefloquine plus cotrimoxazole vs cotrimoxazole | RR 0.52 [0.3, 0.93] | 2 studies · 989 participants | Moderate Downgraded: risk of bias |
Placental malaria (PCR) Mefloquine plus cotrimoxazole vs cotrimoxazole | RR 0.28 [0.14, 0.57] | 2 studies · 977 participants | High |
Maternal anaemia at delivery Mefloquine plus cotrimoxazole vs cotrimoxazole | RR 0.94 [0.73, 1.2] | 2 studies · 1197 participants | Moderate Downgraded: risk of bias |
Low birth weight Mefloquine plus cotrimoxazole vs cotrimoxazole | RR 1.2 [0.89, 1.6] | 2 studies · 1220 participants | Moderate Downgraded: risk of bias |
Spontaneous abortions and stillbirths Mefloquine plus cotrimoxazole vs cotrimoxazole | RR 1.12 [0.42, 2.98] | 2 studies · 1347 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
AEs: vomiting Mefloquine plus cotrimoxazole vs cotrimoxazole | RR 7.95 [4.79, 13.18] | 1 study · 1055 participants | High |
AEs: dizziness Mefloquine plus cotrimoxazole vs cotrimoxazole | RR 3.94 [2.85, 5.46] | 1 study · 1055 participants | High |