Cochrane · systematic review · CD011412
Antiepileptic drug monotherapy for epilepsy: a network meta‐analysis of individual participant data
Nevitt, SJ, Sudell, M, Cividini, S, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
12
No studies
3
Included studies
NR
No studies 3 · 20%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 12 · 80%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlySummary of findings ‐ Time to treatment failure for individuals with focal seizures (reference carbamazepine)
Population: adults and children with focal seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Any reason | no estimate extracted | 4 studies · 520 participants | High |
Adverse events | no estimate extracted | 4 studies · 520 participants | High |
Lack of efficacy | no estimate extracted | 3 studies · 388 participants | High |
Summary of findings ‐ Time to treatment failure for individuals with focal seizures (reference lamotrigine)
Population: adults and children with focal seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Any reason | no estimate extracted | 9 studies · 2203 participants | High |
Adverse events | no estimate extracted | 9 studies · 2203 participants | High |
Lack of efficacy | no estimate extracted | 8 studies · 2098 participants | High |
Summary of findings ‐ Time to treatment failure for individuals with generalised seizures (reference sodium valproate)
Population: adults and children with generalised tonic‐clonic seizures with or without other seizure types
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Any reason | no estimate extracted | 4 studies · 405 participants | High |
Adverse events | no estimate extracted | 2 studies · 117 participants | High |
Lack of efficacy | no estimate extracted | 4 studies · 405 participants | High |
Summary of findings ‐ Time to 12‐month remission for individuals with focal seizures (reference carbamazepine)
Population: adults and children with focal seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Comparison (reference treatment) | no estimate extracted | NR | No studies |
Carbamazepine | no estimate extracted | 4 studies · 525 participants | High |
Summary of findings ‐ Time to 12‐month remission for individuals with focal seizures (reference lamotrigine)
Population: adults and children with focal seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Comparison (reference treatment) | no estimate extracted | NR | No studies |
Lamotrigine | no estimate extracted | 2 studies · 907 participants | High |
Summary of findings ‐ Time to 12‐month remission for individuals with generalised seizures (reference sodium valproate)
Population: adults and children with generalised seizures*
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Comparison (reference treatment) | no estimate extracted | NR | No studies |
Sodium valproate | no estimate extracted | 4 studies · 412 participants | High |
Summary of findings ‐ Time to withdrawal of allocated treatment for individuals with partial seizures
Population: adults and children with partial seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Carbamazepine | no estimate extracted | 4 studies · 520 participants | High |
Summary of findings ‐ Time to withdrawal of allocated treatment for individuals with partial seizures
Population: adults and children with partial seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lamotrigine | no estimate extracted | 9 studies · 2268 participants | High |
Summary of findings ‐ Time to withdrawal of allocated treatment for individuals with generalised seizures
Population: adults and children with generalised seizures*
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sodium Valproate | no estimate extracted | 4 studies · 405 participants | High |
Summary of findings ‐ Time to 12‐month remission for individuals with partial seizures
Population: adults and children with partial seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Carbamazepine | no estimate extracted | 4 studies · 525 participants | High |
Summary of findings ‐ Time to 12‐month remission for individuals with partial seizures
Population: adults and children with partial seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lamotrigine | no estimate extracted | 2 studies · 891 participants | High |
Summary of findings ‐ Time to 12‐month remission for individuals with generalised seizures
Population: adults and children with generalised seizures*
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sodium Valproate | no estimate extracted | 4 studies · 412 participants | High |
Summary of findings ‐ Time to withdrawal of allocated treatment for individuals with partial seizures
Population: adults and children with partial seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Carbamazepine | no estimate extracted | 4 studies · 520 participants | High |
Summary of findings ‐ Time to withdrawal of allocated treatment for individuals with partial seizures
Population: adults and children with partial seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lamotrigine | no estimate extracted | 9 studies · 2268 participants | High |
Summary of findings ‐ Time to withdrawal of allocated treatment for individuals with generalised seizures
Population: adults and children with generalised seizures*
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sodium Valproate | no estimate extracted | 4 studies · 405 participants | High |
Summary of findings ‐ Time to 12‐month remission for individuals with partial seizures
Population: adults and children with partial seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Carbamazepine | no estimate extracted | 4 studies · 525 participants | High |
Summary of findings ‐ Time to 12‐month remission for individuals with partial seizures
Population: adults and children with partial seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lamotrigine | no estimate extracted | 2 studies · 891 participants | High |
Summary of findings ‐ Time to 12‐month remission for individuals with generalised seizures
Population: adults and children with generalised seizures*
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sodium Valproate | no estimate extracted | 4 studies · 412 participants | High |