Cochrane · systematic review · CD011370
Adjunctive steroid therapy for managing pulmonary tuberculosis
Critchley, JA, Orton, LC, Pearson, F · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 25%Low 2 · 50%Moderate 1 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Steroid therapy comparative to either no therapy or placebo for managing pulmonary tuberculosis
Population: patients with managing pulmonary tuberculosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality | RR 0.77 [0.51, 1.15] | 18 studies · 3815 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Sputum Conversion by 2 months | RR 1.1 [1.03, 1.17] | 11 studies · 1475 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Sputum conversion at 6 months | RR 1.01 [0.97, 1.05] | 8 studies · 875 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness, publication bias |
Clinical Improvement at 1 month | RR 1.16 [1.09, 1.24] | 5 studies · 497 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |