Cochrane · systematic review · CD011305
Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support
Radford, M, Estcourt, LJ, Sirotich, E, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
9
No studies
5
Included studies
NR
No studies 5 · 35.7%Ungraded 0 · 0%Very low 4 · 28.6%Low 4 · 28.6%Moderate 1 · 7.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlySummary of findings
Population: Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality at 31 to 100 days | RR 1 [0.27, 3.7] | 3 studies · 451 participants | Very low Downgraded: risk of bias |
Quality of life (0 to 3 months) | no estimate extracted | 3 studies · 431 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Number of participants with any bleeding (0 to 3 months) | RR 0.91 [0.78, 1.06] | 3 studies · 448 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Number of participants with clinically significant bleeding (0 to 3 months) | RR 0.94 [0.74, 1.19] | 4 studies · 511 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Serious infections (0 to 3 months) | RR 1.2 [0.93, 1.55] | 3 studies · 451 participants | Low Downgraded: risk of bias |
Length of hospital admission (days) (0 to 3 months) | no estimate extracted | 2 studies · 388 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Hospital readmission (0 to 3 months) | RR 0.89 [0.52, 1.5] | 1 study · 299 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Summary of findings of NRS
Population: Adults with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality at 31 to 100 days | no estimate extracted | 1 study · 84 participants | Very low Downgraded: risk of bias |
Quality of life ‐ not reported | no estimate extracted | NR | No studies |
Number of participants with any bleeding ‐ not reported | no estimate extracted | NR | No studies |
Number of participants with clinically significant bleeding | no estimate extracted | 1 study · 84 participants | Very low Downgraded: risk of bias |
Serious infections ‐ not reported | no estimate extracted | NR | No studies |
Length of hospital admission ‐ not reported | no estimate extracted | NR | No studies |
Hospital readmission rate ‐ not reported | no estimate extracted | NR | No studies |
Comparison
Population: people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality at 31 to 100 days | RR 0.25 [0.02, 2.69] | 2 studies · 95 participants | Low Downgraded: imprecision |
Quality of life | no estimate extracted | 1 study · 89 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Number of participants with any bleeding | RR 0.93 [0.73, 1.18] | 2 studies · 149 participants | Low Downgraded: imprecision, indirectness |
Number of participants with clinically significant bleeding | RR 1.03 [0.75, 1.43] | 2 studies · 149 participants | Low Downgraded: imprecision, indirectness |
Serious infections | RR 1.23 [0.74, 2.04] | 1 study · 89 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Length of hospital admission (days) | no estimate extracted | 1 study · 89 participants | Low Downgraded: imprecision, indirectness |
Hospital readmission rate ‐ not reported | no estimate extracted | NR | No studies |
Summary of findings of NRS
Population: people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality at 31 to 100 days | no estimate extracted | 1 study · 84 participants | Very low Downgraded: imprecision |
Quality of life ‐ not reported | no estimate extracted | NR | No studies |
Number of participants with any bleeding ‐ not reported | no estimate extracted | NR | No studies |
Number of participants with clinically significant bleeding | no estimate extracted | 1 study · 84 participants | Very low Downgraded: imprecision |
Serious infections ‐ not reported | no estimate extracted | NR | No studies |
Length of hospital admission ‐ not reported | no estimate extracted | NR | No studies |
Hospital readmission rate ‐ not reported | no estimate extracted | NR | No studies |