Cochrane · systematic review · CD011192
Calcium supplementation commencing before or early in pregnancy, for preventing hypertensive disorders of pregnancy
Hofmeyr, GJ, Manyame, S, Medley, N, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 11.1%Low 8 · 88.9%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyCalcium supplementation versus placebo (maternal outcomes) commencing before or early in pregnancy, for preventing hypertensive disorders of pregnancy
Population: women who are not yet pregnant and women in the early stages of pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pre‐eclampsia Calcium supplementation vs placebo (maternal outcomes) commencing before or early | RR 0.8 [0.61, 1.06] | 1 study · 579 participants | Low Downgraded: imprecision |
Pre‐eclampsia, or pregnancy loss, or stillbirth (or combination) at any gestational age Calcium supplementation vs placebo (maternal outcomes) commencing before or early | RR 0.82 [0.66, 1] | 1 study · 633 participants | Low Downgraded: risk of bias, imprecision |
Severe maternal morbidity and mortality index Calcium supplementation vs placebo (maternal outcomes) commencing before or early | RR 0.93 [0.68, 1.26] | 1 study · 579 participants | Low Downgraded: imprecision |
Pregnancy loss or stillbirth at any gestational age Calcium supplementation vs placebo (maternal outcomes) commencing before or early | RR 0.83 [0.61, 1.14] | 1 study · 633 participants | Low Downgraded: imprecision |
Caesarean section Calcium supplementation vs placebo (maternal outcomes) commencing before or early | RR 1.11 [0.96, 1.28] | 1 study · 578 participants | Low Downgraded: imprecision |
Calcium compared to placebo (offspring outcomes) commencing before or early in pregnancy, for preventing hypertensive disorders of pregnancy
Population: women who are not yet pregnant, and women in the early stages of pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Birthweight < 2500 g Calcium vs placebo (offspring outcomes) commencing before or early | RR 1 [0.76, 1.3] | 1 study · 507 participants | Low Downgraded: imprecision |
Apgar < 7 at 5 minutes Calcium vs placebo (offspring outcomes) commencing before or early | RR 0.43 [0.15, 1.21] | 1 study · 494 participants | Very low Downgraded: risk of bias, imprecision |
Perinatal death, or NICU admission for > 24 hours (or both) Calcium vs placebo (offspring outcomes) commencing before or early | RR 1.11 [0.77, 1.6] | 1 study · 508 participants | Low Downgraded: imprecision |
Pregnancy loss, stillbirth or NND before discharge Calcium vs placebo (offspring outcomes) commencing before or early | RR 0.82 [0.61, 1.1] | 1 study · 632 participants | Low Downgraded: risk of bias, imprecision |
Calcium +/‐ other supplements compared to no calcium or placebo for pregnancy, or food fortification with calcium, for preventing hypertensive disorders of pregnancy
Population: pregnant women with confirmed low antioxidant levels
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pre‐eclampsia (gestational hypertension and proteinuria) Calcium +/‐ other supplements vs no calcium or placebo | RR 0.24 [0.06, 1.01] | 1 study · 60 participants | Low Downgraded: risk of bias, imprecision |
Pre‐eclampsia and/or pregnancy loss at any gestational age Calcium +/‐ other supplements vs no calcium or placebo | RR 0.13 [0.03, 0.5] | 1 study · 60 participants | Moderate Downgraded: risk of bias, imprecision |
Severe maternal morbidity and mortality index Calcium +/‐ other supplements vs no calcium or placebo | RR 0.36 [0.04, 3.23] | 1 study · 60 participants | Low Downgraded: risk of bias, imprecision |
Pregnancy loss/stillbirth at any gestational age Calcium +/‐ other supplements vs no calcium or placebo | RR 0.06 [0, 0.92] | 1 study · 60 participants | Moderate Downgraded: risk of bias, imprecision |
Caesarean section Calcium +/‐ other supplements vs no calcium or placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Birthweight < 2500 g Calcium +/‐ other supplements vs no calcium or placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Apgar score less than 7 at 5 minutes Calcium +/‐ other supplements vs no calcium or placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Death or admission to neonatal ICU for 24 hours or more Calcium +/‐ other supplements vs no calcium or placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Pregnancy loss, stillbirth or neonatal death before discharge Calcium +/‐ other supplements vs no calcium or placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |