Cochrane · systematic review · CD011188
Corticosteroids for the treatment of Kawasaki disease in children
Green, J, Wardle, AJ, Tulloh, RMR · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 5 · 71.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyCorticosteroids compared to no corticosteroid use for the treatment of Kawasaki disease in children
Population: children diagnosed with Kawasaki disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of coronary artery abnormalities Corticosteroids vs no corticosteroid use | OR 0.32 [0.14, 0.75] | 8 studies · 986 participants | Moderate Downgraded: inconsistency |
Incidence of any serious adverse effects attributable to the administration of corticosteroids Corticosteroids vs no corticosteroid use | no estimate extracted | 6 studies · 737 participants | Moderate Downgraded: imprecision |
Mortality (all‐cause) Corticosteroids vs no corticosteroid use | no estimate extracted | 8 studies · 1075 participants | Moderate Downgraded: imprecision |
Duration of clinical symptoms: fever and rash (days) Corticosteroids vs no corticosteroid use | no estimate extracted | 3 studies · 290 participants | Low Downgraded: imprecision, inconsistency, indirectness |
Time for laboratory parameters to normalise: CRP, ESRe (days) Corticosteroids vs no corticosteroid use | no estimate extracted | 1 study · 178 participants | Moderate Downgraded: imprecision |
Length of hospital stay (days) Corticosteroids vs no corticosteroid use | no estimate extracted | 2 studies · 119 participants | Moderate Downgraded: imprecision, indirectness |
Longer term (> 1 year after disease onset) coronary morbidity (non‐aneurysmal) Corticosteroids vs no corticosteroid use | no estimate extracted | NR | No studies |
Summary of findings table: Corticosteroids versus no corticosteroid use for treatment if Kawasaki disease in children
Population: children diagnosed with Kawasaki disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of coronary artery abnormalities Duration: 2 to 6 weeks Summary of findings table: Corticosteroids vs no corticosteroid use | OR 0.29 [0.18, 0.46] | 7 studies · 907 participants | Moderate Downgraded: inconsistency |
Incidence of serious adverse effects attributable to steroid use Duration: 2 to 6 weeks Summary of findings table: Corticosteroids vs no corticosteroid use | no estimate extracted | 6 studies · 737 participants | High |
Mortality (all‐cause) Duration: 2 to 6 weeks Summary of findings table: Corticosteroids vs no corticosteroid use | no estimate extracted | 7 studies · 915 participants | High |
Duration of clinical symptoms: fever, rash (days) Duration: N/A Summary of findings table: Corticosteroids vs no corticosteroid use | no estimate extracted | 2 studies · 210 participants | Moderate Downgraded: inconsistency |
Time for laboratory parameters to normalise: CRP, ESR (days) Duration: N/A Summary of findings table: Corticosteroids vs no corticosteroid use | no estimate extracted | 1 study · 178 participants | High |
Length of hospital stay (days) Duration: N/A Summary of findings table: Corticosteroids vs no corticosteroid use | no estimate extracted | 1 study · 39 participants | Moderate |
Longer‐term (> 1 year post disease onset) coronary morbidity (non‐aneurysmal) Duration: N/A Summary of findings table: Corticosteroids vs no corticosteroid use | no estimate extracted | NR | No studies |