Cochrane · systematic review · CD010678
Artemether for severe malaria
Esu, EB, Effa, EE, Opie, ON, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 6.7%Very low 0 · 0%Low 6 · 40%Moderate 8 · 53.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version only‘Summary of findings' table 1
Population: children with severe malaria
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death | RR 0.97 [0.77, 1.21] | 13 studies · 1659 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Coma resolution time | no estimate extracted | 6 studies · 358 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Neurological sequelae at discharge | RR 0.84 [0.66, 1.07] | 7 studies · 968 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Parasite clearance time | no estimate extracted | 7 studies · 420 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Fever clearance time | no estimate extracted | 8 studies · 457 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
‘Summary of findings' table 2
Population: adults with severe malaria
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death | RR 0.59 [0.42, 0.83] | 4 studies · 716 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Coma resolution time | no estimate extracted | 2 studies · 657 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Neurological sequelae at discharge | RR 2.92 [0.31, 27.86] | 1 study · 560 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Parasite clearance time | no estimate extracted | 4 studies · 716 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Fever clearance time | no estimate extracted | 4 studies · 716 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
‘Summary of findings' table 3
Population: adults with severe malaria
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death | RR 1.8 [1.09, 2.97] | 2 studies · 494 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Coma resolution time | no estimate extracted | 2 studies · 494 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Neurological sequelae at discharge | no estimate extracted | 0 studies · 0 participants | Ungraded |
Parasite clearance time | no estimate extracted | 2 studies · 494 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Fever clearance time | no estimate extracted | 2 studies · 494 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Summary of findings table 1
Population: Children with severe malaria
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death | RR 0.96 [0.76, 1.2] | 12 studies · 1447 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Coma resolution time | no estimate extracted | 6 studies · 358 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Neurological sequelae at discharge | RR 0.84 [0.66, 1.07] | 7 studies · 968 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Parasite clearance time | no estimate extracted | 7 studies · 420 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Fever clearance time | no estimate extracted | 8 studies · 457 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Summary of findings table 2
Population: Adults with severe malaria
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death | RR 0.59 [0.42, 0.83] | 4 studies · 716 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Coma resolution time | no estimate extracted | 2 studies · 657 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Neurological sequelae at discharge | RR 2.92 [0.31, 27.86] | 1 study · 560 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Parasite clearance time | no estimate extracted | 4 studies · 716 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Fever clearance time | no estimate extracted | 4 studies · 716 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Summary of findings table 3
Population: Adults with severe malaria
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death | RR 1.8 [1.09, 2.97] | 2 studies · 494 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Coma resolution time | no estimate extracted | 2 studies · 494 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Neurological sequelae at discharge | no estimate extracted | 0 studies · 0 participants | Ungraded |
Parasite clearance time | no estimate extracted | 2 studies · 494 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Fever clearance time | no estimate extracted | 2 studies · 494 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |