Cochrane · systematic review · CD010599
Anthelmintic drugs for treating ascariasis
Conterno, LO, Turchi, MD, Corrêa, I, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
12
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 16.7%Moderate 5 · 41.7%High 5 · 41.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Any anthelmintic drug single dose compared to placebo for treating ascariasis
Population: children and adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Parasitological cure Any anthelmintic drug single dose vs placebo | RR 6.29 [3.91, 10.12] | 8 studies · 1578 participants | Moderate Downgraded: inconsistency |
Faecal egg count Any anthelmintic drug single dose vs placebo | no estimate extracted | 5 studies · 1020 participants | High |
Adverse events Any anthelmintic drug single dose vs placebo | no estimate extracted | 4 studies · 744 participants | Moderate Downgraded: risk of bias |
Albendazole 400 mg single dose compared to albendazole 400 mg multiple doses for treating ascariasis
Population: children and adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Parasitological cure Albendazole 400 mg single dose vs albendazole 400 mg multiple doses | RR 0.98 [0.92, 1.05] | 3 studies · 307 participants | High |
Faecal eggs count Albendazole 400 mg single dose vs albendazole 400 mg multiple doses | no estimate extracted | 2 studies · 249 participants | Moderate Downgraded: imprecision |
Adverse events Albendazole 400 mg single dose vs albendazole 400 mg multiple doses | no estimate extracted | 3 studies · 316 participants | Moderate Downgraded: imprecision |
Albendazole 400 mg single dose compared to mebendazole 500 mg single dose for treating ascariasis
Population: children and adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Parasitological cure Albendazole 400 mg single dose vs mebendazole 500 mg single dose | RR 1.01 [1, 1.02] | 6 studies · 2131 participants | High |
Faecal egg count Albendazole 400 mg single dose vs mebendazole 500 mg single dose | no estimate extracted | 5 studies · 1902 participants | High |
Adverse events Albendazole 400 mg single dose vs mebendazole 500 mg single dose | no estimate extracted | 5 studies · 1902 participants | Low Downgraded: risk of bias, imprecision |
Albendazole single dose compared to ivermectin single dose cure rate for treating ascariasis
Population: children and adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Parasitological cure Albendazole single dose vs ivermectin single dose cure rate | RR 0.99 [0.91, 1.08] | 3 studies · 519 participants | Moderate Downgraded: inconsistency |
Faecal egg count Albendazole single dose vs ivermectin single dose cure rate | no estimate extracted | 2 studies · 315 participants | High |
Adverse outcomes Albendazole single dose vs ivermectin single dose cure rate | no estimate extracted | 1 study · 204 participants | Low Downgraded: risk of bias, imprecision |