Cochrane · systematic review · CD010561
Immune tolerance induction for treating inhibitors in people with congenital haemophilia A or B
Athale, AH, Marcucci, M, Iorio, A · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Cystic Fibrosis and Genetic DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
3
No studies
2
Included studies
NR
No studies 2 · 40%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 20%Moderate 2 · 40%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: persons with severe haemophilia A and factor inhibitory antibodies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total ITI Success | RR 1.07 [0.68, 1.68] | 1 study · 115 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
All bleeding events | RR 1.36 [1.09, 1.71] | 1 study · 115 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
CVAD infections | RR 0.96 [0.6, 1.53] | 1 study · 99 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Severe allergic reaction | no estimate extracted | NR | No studies |
Nephrotic symdrome | no estimate extracted | NR | No studies |