Cochrane · systematic review · CD010541
Surgery for epilepsy
West, S, Nevitt, SJ, Cotton, J, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 12.5%Low 6 · 75%Moderate 1 · 12.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyComparison
Population: adults and children with drug‐resistant epilepsy suitable for surgical intervention
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion free from seizures at 1 year | RR 9.78 [4.73, 20.21] | 2 studies · 196 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Proportion free from all seizures (including auras) at 1 year | RR 15 [2.08, 108.23] | 1 study · 80 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Comparison
Population: adults and children with drug‐resistant epilepsy suitable for surgical intervention
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion free from seizures (Engel Class 1 or 1A) at 1 year and at 5 years | no estimate extracted | 1 study · 43 participants | Low Downgraded: risk of bias |
P roportion with remission of seizures (at least Engel Class IB) between 25 and 36 months | RR 0.66 [0.45, 0.99] | 1 study · 58 participants | Low Downgraded: risk of bias, indirectness |
Proportion free from seizures (Engel Class 1) at 1 year | RR 1.14 [0.76, 1.7] | 1 study · 43 participants | Low Downgraded: risk of bias, indirectness |
Proportion free from seizures (Engel Class 1) at 2 years | RR 1.22 [0.85, 1.76] | 1 study · 60 participants | Moderate Downgraded: risk of bias, indirectness |
Proportion free from all seizures (including auras, ILAE 1a) at 1 year | RR 0.92 [0.59, 1.46] | 1 study · 47 participants | Low Downgraded: risk of bias, indirectness |
Proportion free from all seizures (including auras) at 1 year | RR 1.82 [1.12, 2.93] | 1 study · 70 participants | Low Downgraded: risk of bias, indirectness |
Comparison
Population: adults with drug‐resistant epilepsy suitable for surgical intervention
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion free from seizure impairing awareness at 1 year | RR 7.67 [2.5, 23.51] | 1 study · 80 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Proportion free from all seizures (including auras) at 1 year | RR 15 [2.08, 108.23] | 1 study · 80 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Comparison
Population: adults and children with drug‐resistant epilepsy suitable for surgical intervention
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion free from seizures (Engel Class 1) at 2 years | RR 1.22 [0.85, 1.76] | 1 study · 60 participants | Moderate Downgraded: risk of bias, indirectness |
Proportion free from seizures (Engel Class 1) at 1 year | RR 1.02 [0.86, 1.2] | 1 study · 207 participants | Moderate Downgraded: risk of bias, indirectness |
Proportion free from all seizures (including auras) at 1 year | RR 1.82 [1.12, 2.93] | 1 study · 70 participants | Low Downgraded: risk of bias, indirectness |