Cochrane · systematic review · CD010378
Prophylactic versus selective blood transfusion for sickle cell disease in pregnancy
Okusanya, BO, Oladapo, OT · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 5 · 71.4%Low 2 · 28.6%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyProphylactic versus selective blood transfusion for sickle cell disease in pregnancy
Population: patients with sickle cell disease in pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal death Prophylactic vs selective blood transfusion | no estimate extracted | 1 study · 72 participants | Very low Downgraded: risk of bias |
Severe maternal morbidity (pulmonary embolism) Prophylactic vs selective blood transfusion | no estimate extracted | 1 study · 72 participants | Very low Downgraded: risk of bias |
Severe maternal morbidity (congestive cardiac failure) Prophylactic vs selective blood transfusion | RR 1 [0.07, 15.38] | 1 study · 72 participants | Very low Downgraded: risk of bias, imprecision |
Perinatal death Prophylactic vs selective blood transfusion | RR 2.85 [0.61, 13.22] | 1 study · 76 participants | Very low Downgraded: risk of bias, imprecision |
Sickle cell crisis (pain crisis) Prophylactic vs selective blood transfusion | RR 0.28 [0.12, 0.67] | 1 study · 72 participants | Low Downgraded: risk of bias, imprecision |
Sickle cell crises (acute splenic sequestration) Prophylactic vs selective blood transfusion | RR 0.33 [0.01, 7.92] | 1 study · 72 participants | Low Downgraded: risk of bias, imprecision |
Blood transfusion reaction Prophylactic vs selective blood transfusion | RR 2 [0.54, 7.39] | 1 study · 72 participants | Very low Downgraded: risk of bias, imprecision |
Prophylactic versus selective blood transfusion for sickle cell disease in pregnancy
Population: patients with sickle cell disease in pregnancy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal death Prophylactic vs selective blood transfusion | no estimate extracted | 1 study · 72 participants | Very low Downgraded: risk of bias, imprecision |
Severe maternal morbidity (pulmonary embolism) Prophylactic vs selective blood transfusion | no estimate extracted | 1 study · 72 participants | Very low Downgraded: risk of bias, imprecision |
Severe maternal morbidity (congestive cardiac failure) Prophylactic vs selective blood transfusion | RR 1 [0.07, 15.38] | 1 study · 72 participants | Very low Downgraded: risk of bias, imprecision |
Perinatal death Prophylactic vs selective blood transfusion | RR 2.85 [0.61, 13.22] | 1 study · 76 participants | Very low Downgraded: risk of bias, imprecision |
Sickle cell crisis (pain crisis) Prophylactic vs selective blood transfusion | RR 0.42 [0.17, 0.99] | 2 studies · 98 participants | Low Downgraded: risk of bias |
Sickle cell crises (acute splenic sequestration) Prophylactic vs selective blood transfusion | RR 0.33 [0.01, 7.92] | 1 study · 72 participants | Very low Downgraded: risk of bias, imprecision |
Blood transfusion reaction Prophylactic vs selective blood transfusion | RR 2 [0.54, 7.39] | 1 study · 72 participants | Very low Downgraded: risk of bias, imprecision |