Cochrane · systematic review · CD010315
Blood pressure targets for the treatment of people with hypertension and cardiovascular disease
Saiz, LC, Gorricho, J, Garjón, J, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 20%Low 2 · 40%Moderate 2 · 40%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyLower blood pressure targets compared with standard blood pressure targets for mortality and morbidity
Population: cardiovascular disease with high blood pressure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total mortality Lower blood pressure targets vs standard blood pressure targets | RR 1.05 [0.91, 1.23] | 7 studies · 9595 participants | Moderate Downgraded: imprecision |
Total serious adverse events Lower blood pressure targets vs standard blood pressure targets | RR 1.01 [0.94, 1.08] | 7 studies · 9595 participants | Low Downgraded: risk of bias, imprecision |
Total cardiovascular events Lower blood pressure targets vs standard blood pressure targets | RR 0.89 [0.8, 1] | 7 studies · 9595 participants | Low Downgraded: risk of bias, imprecision |
Cardiovascular mortality Lower blood pressure targets vs standard blood pressure targets | RR 1.03 [0.82, 1.29] | 6 studies · 9484 participants | Moderate Downgraded: imprecision |
Participant withdrawals due to adverse effects Lower blood pressure targets vs standard blood pressure targets | RR 8.16 [2.06, 32.28] | 3 studies · 801 participants | Very low Downgraded: risk of bias, imprecision |
Lower blood pressure targets compared with standard blood pressure targets for mortality and morbidity
Population: cardiovascular disease with high blood pressure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total mortality Lower blood pressure targets vs standard blood pressure targets | RR 1.06 [0.91, 1.23] | 6 studies · 9484 participants | Moderate Downgraded: imprecision |
Total serious adverse events Lower blood pressure targets vs standard blood pressure targets | RR 1.01 [0.94, 1.08] | 6 studies · 9484 participants | Low Downgraded: risk of bias, imprecision |
Total cardiovascular events Lower blood pressure targets vs standard blood pressure targets | RR 0.89 [0.8, 1] | 6 studies · 9484 participants | Low Downgraded: risk of bias, imprecision |
Cardiovascular mortality Lower blood pressure targets vs standard blood pressure targets | RR 1.03 [0.82, 1.29] | 6 studies · 9484 participants | Moderate Downgraded: imprecision |
Participant withdrawals due to adverse effects Lower blood pressure targets vs standard blood pressure targets | RR 8.16 [2.06, 32.28] | 2 studies · 690 participants | Very low Downgraded: risk of bias, imprecision |
Lower blood pressure targets compared with standard blood pressure targets for mortality and morbidity
Population: cardiovascular disease with high blood pressure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total mortality Lower blood pressure targets vs standard blood pressure targets | RR 1.06 [0.91, 1.23] | 6 studies · 9484 participants | Moderate Downgraded: imprecision |
Serious adverse events Lower blood pressure targets vs standard blood pressure targets | RR 1.01 [0.94, 1.08] | 6 studies · 9484 participants | Low Downgraded: imprecision |
Total cardiovascular events Lower blood pressure targets vs standard blood pressure targets | RR 0.89 [0.8, 1] | 6 studies · 9484 participants | Low Downgraded: imprecision |
Cardiovascular mortality Lower blood pressure targets vs standard blood pressure targets | RR 1.03 [0.82, 1.29] | 6 studies · 9484 participants | Moderate Downgraded: imprecision |
Withdrawals due to adverse effects Lower blood pressure targets vs standard blood pressure targets | RR 8.16 [2.06, 32.28] | 2 studies · 690 participants | Very low Downgraded: imprecision |
Lower blood pressure targets compared with standard blood pressure targets for mortality and morbidity
Population: Cardiovascular disease with high blood pressure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total mortality Lower blood pressure targets vs standard blood pressure targets | RR 1.05 [0.9, 1.22] | 6 studies · 9795 participants | Moderate Downgraded: imprecision |
Serious adverse events Lower blood pressure targets vs standard blood pressure targets | RR 1.02 [0.95, 1.11] | 6 studies · 9795 participants | Low Downgraded: imprecision |
Total cardiovascular events Lower blood pressure targets vs standard blood pressure targets | RR 0.87 [0.78, 0.98] | 6 studies · 9795 participants | Low Downgraded: imprecision |
Cardiovascular mortality Lower blood pressure targets vs standard blood pressure targets | RR 0.96 [0.77, 1.21] | 6 studies · 9795 participants | Moderate Downgraded: imprecision |
Withdrawals due to adverse effects Lower blood pressure targets vs standard blood pressure targets | RR 8.16 [2.06, 32.28] | 2 studies · 690 participants | Very low Downgraded: imprecision |