Cochrane · systematic review · CD010196
Different unfractionated heparin doses for preventing arterial thrombosis in children undergoing cardiac catheterization
Avila, ML, Shah, PS, Brandão, LR · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
4
No studies
1
Included studies
NR
No studies 1 · 20%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 4 · 80%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyDifferent unfractionated heparin doses for preventing arterial thrombosis in children undergoing cardiac catheterization
Population: children with congenital heart disease undergoing CC
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Arterial thrombotic events (6 to 48 hours after CC) | RR 1.06 [0.58, 1.92] | 2 studies · 492 participants | Moderate Downgraded: risk of bias, imprecision |
Major bleeding events (timing not specified) | RR 2.96 [0.12, 71.34] | 1 study · 137 participants | Moderate Downgraded: imprecision |
Minor bleeding events (timing not specified) | RR 1.38 [0.46, 4.13] | 1 study · 137 participants | Moderate Downgraded: imprecision |
Other thrombotic events: venous thrombosis (up to 48 hours after CC) | RR 0.34 [0.01, 8.28] | 1 study · 126 participants | Moderate Downgraded: imprecision |
Additional side effects of heparin | no estimate extracted | NR | No studies |
Comparison
Population: children with congenital heart disease undergoing cardiac catheterization
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Arterial thrombosis (6‐48 hours after CC) | RR 1.06 [0.58, 1.92] | 2 studies · 492 participants | Moderate Downgraded: risk of bias, imprecision |
Minor bleeding | RR 1.38 [0.46, 4.13] | 1 study · 137 participants | Moderate Downgraded: imprecision |
Major bleeding | RR 2.96 [0.12, 71.34] | 1 study · 137 participants | Moderate Downgraded: imprecision |
Venous thrombosis | RR 0.34 [0.01, 8.28] | 1 study · 126 participants | Moderate Downgraded: imprecision |