Cochrane · systematic review · CD010137
Glucose targets for preventing diabetic kidney disease and its progression
Ruospo, M, Saglimbene, VM, Palmer, SC, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 12.5%Low 3 · 37.5%Moderate 4 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Tight glycaemic control compared with non‐tight control for preventing diabetic kidney disease (DKD) and its progression
Population: patients with diabetes
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Doubling serum creatinine 8.3 years Tight glycaemic control vs non‐tight control | RR 0.84 [0.64, 1.11] | 4 studies · 26874 participants | Low |
ESKD 5.9 years Tight glycaemic control vs non‐tight control | RR 0.62 [0.34, 1.12] | 4 studies · 23332 participants | Low |
Sudden death 4.6 years Tight glycaemic control vs non‐tight control | RR 0.82 [0.26, 2.57] | 4 studies · 5913 participants | Very low |
All‐cause mortality 5.6 years Tight glycaemic control vs non‐tight control | RR 0.99 [0.86, 1.13] | 9 studies · 29094 participants | Moderate |
Cardiovascular mortality 4.4 years Tight glycaemic control vs non‐tight control | RR 1.19 [0.73, 1.92] | 6 studies · 23673 participants | Low |
Non‐fatal myocardial infarction 5.6 years Tight glycaemic control vs non‐tight control | RR 0.82 [0.67, 0.99] | 5 studies · 25596 participants | Moderate |
Onset microalbuminuria 5.4 years Tight glycaemic control vs non‐tight control | RR 0.85 [0.77, 0.94] | 4 studies · 19933 participants | Moderate |
Progression of microalbuminuria 5.8 years Tight glycaemic control vs non‐tight control | RR 0.59 [0.38, 0.93] | 5 studies · 13266 participants | Moderate |