Cochrane · systematic review · CD010037
Calcium supplementation for prevention of primary hypertension
Cormick, G, Ciapponi, A, Cafferata, ML, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
7
No studies
1
Included studies
NR
No studies 1 · 12.5%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 37.5%High 4 · 50%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyCalcium supplementation/fortification compared to control for prevention of primary hypertension
Population: People who may be at risk for primary hypertension
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Systolic blood pressure (range of Calcium supplementation/fortification vs control | no estimate extracted | 18 studies · 3140 participants | High |
Diastolic blood pressure (range of Calcium supplementation/fortification vs control | no estimate extracted | 17 studies · 3039 participants | High |
Systolic blood pressure. Dose less than 1000 mg a day (range of Calcium supplementation/fortification vs control | no estimate extracted | 3 studies · 302 participants | Moderate Downgraded: imprecision |
Systolic blood pressure. Dose between 1000 mg a day and less than 1500 mg a day (range of Calcium supplementation/fortification vs control | no estimate extracted | 9 studies · 2488 participants | High |
Systolic blood pressure. Dose 1500 mg a day or more (range of Calcium supplementation/fortification vs control | no estimate extracted | 7 studies · 350 participants | Moderate Downgraded: imprecision |
Systolic blood pressure. Less than 35 years of age (range of Calcium supplementation/fortification vs control | no estimate extracted | 9 studies · 452 participants | Moderate Downgraded: imprecision |
Systolic blood pressure. 35 years or older (range of Calcium supplementation/fortification vs control | no estimate extracted | 10 studies · 2688 participants | High |
Adverse events (secondary outcome) Calcium supplementation/fortification vs control | no estimate extracted | NR | No studies |
Calcium supplementation/fortification compared to control for prevention of primary hypertension
Population: People who may be at risk for primary hypertension
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Systolic blood pressure (range of Calcium supplementation/fortification vs control | no estimate extracted | 18 studies · 3140 participants | High |
Diastolic blood pressure (range of Calcium supplementation/fortification vs control | no estimate extracted | 17 studies · 3039 participants | High |
Systolic blood pressure. Dose less than 1000 mg a day (range of Calcium supplementation/fortification vs control | no estimate extracted | 3 studies · 302 participants | Moderate Downgraded: imprecision |
Systolic blood pressure. Dose between 1000 mg a day and less than 1500 mg a day (range from 4 weeks to 2 years) Calcium supplementation/fortification vs control | no estimate extracted | 9 studies · 2488 participants | High |
Systolic blood pressure. Dose 1500 mg a day or more (range of Calcium supplementation/fortification vs control | no estimate extracted | 7 studies · 350 participants | Moderate Downgraded: imprecision |
Systolic blood pressure. Less than 35 years of age (range of Calcium supplementation/fortification vs control | no estimate extracted | 9 studies · 452 participants | Moderate Downgraded: imprecision |
Systolic blood pressure. 35 years or older (range of Calcium supplementation/fortification vs control | no estimate extracted | 10 studies · 2688 participants | High |
Adverse events (secondary outcome) Calcium supplementation/fortification vs control | no estimate extracted | NR | No studies |
Calcium supplementation/fortification compared to control for prevention of primary hypertension
Population: People who may be at risk for primary hypertension
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Systolic blood pressure Calcium supplementation/fortification vs control | no estimate extracted | 16 studies · 3048 participants | High |
Diastolic blood pressure Calcium supplementation/fortification vs control | no estimate extracted | 15 studies · 2947 participants | High |
Systolic blood pressure. Dose less than 1000 mg a day Calcium supplementation/fortification vs control | no estimate extracted | 2 studies · 263 participants | Moderate Downgraded: imprecision |
Systolic blood pressure. Dose between 1000 mg a day and less than 1500 mg a day Calcium supplementation/fortification vs control | no estimate extracted | 8 studies · 2435 participants | High |
Systolic blood pressure. Dose 1500 mg a day or more Calcium supplementation/fortification vs control | no estimate extracted | 7 studies · 350 participants | Moderate Downgraded: imprecision |
Systolic blood pressure. Less than 35 years of age Calcium supplementation/fortification vs control | no estimate extracted | 7 studies · 399 participants | Moderate Downgraded: imprecision |
Systolic blood pressure. 35 years or older Calcium supplementation/fortification vs control | no estimate extracted | 9 studies · 2649 participants | High |