Cochrane · systematic review · CD010010
Haemophilus influenzae oral vaccination for preventing acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease
Teo, E, Lockhart, K, Purchuri, SN, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 42.9%Low 3 · 42.9%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyHaemophilus influenzae oral vaccination for prevention of acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease (COPD)
Population: adults (> 18 years of age) with either COPD or recurrent acute exacerbations of chronic bronchitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Acute exacerbations (number of exacerbations/person/year) | RR 0.79 [0.57, 1.1] | 6 studies · 557 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Mortality (deaths during trial period) | OR 1.62 [0.63, 4.12] | 5 studies · 518 participants | Very low |
Carriage of NTHi Not meta‐analysed | no estimate extracted | NR | Very low Downgraded: inconsistency |
Antibiotic prescriptions (number of courses/person/year) **Corticosteroids not meta‐analysed | RR 1.81 [1.35, 2.44] | 3 studies · 142 participants | Low Downgraded: risk of bias |
Hospital admissions (number of participants hospitalised during trial period) | no estimate extracted | NR | Moderate Downgraded: imprecision |
Adverse events (number of adverse events/person/year) | RR 1.43 [0.7, 2.92] | 5 studies · 484 participants | Low Downgraded: risk of bias, imprecision |
Quality of life Not meta‐analysed | no estimate extracted | NR | Very low Downgraded: inconsistency |
Comparison
Population: adults (> 18 years of age) with either COPD or recurrent acute exacerbations of chronic bronchitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Acute exacerbations (number of exacerbations/person/year) | RR 0.97 [0.84, 1.12] | 6 studies · 557 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Mortality (deaths during trial period) | OR 1.62 [0.63, 4.12] | 5 studies · 518 participants | Very low |
Carriage of NTHi Not meta‐analysed | no estimate extracted | NR | Very low Downgraded: inconsistency |
Antibiotic prescriptions (number of courses/person/year) **Corticosteroids not meta‐analysed | RR 1.81 [1.35, 2.44] | 3 studies · 142 participants | Low Downgraded: risk of bias |
Hospital admissions (number of patients hospitalised during trial period) | OR 0.96 [0.13, 7.04] | 2 studies · 358 participants | Moderate Downgraded: imprecision |
Adverse events (number of adverse events/person/year) | RR 1.43 [0.7, 2.92] | 4 studies · 484 participants | Low Downgraded: risk of bias, imprecision |
Quality of life Not meta‐analysed | no estimate extracted | NR | Very low Downgraded: inconsistency |