Cochrane · systematic review · CD009861

Melatonin for preoperative and postoperative anxiety in adults

Madsen, BK, Zetner, D, Møller, AM, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library

Anaesthesia2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 1 · 9.1%Ungraded 0 · 0%Very low 1 · 9.1%Low 7 · 63.6%Moderate 2 · 18.2%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Summary of findings

Population: patents undergoing elective surgery

CD009861.PUB3 (current) · 6 questions

Outcome	Effect	Evidence	Status / GRADE
Preoperative anxiety (VAS) VAS (0 to 100 mm) measured approximately 50 to 120 minutes after premedication 0: no anxiety 100: maximum anxiety possible	no estimate extracted	18 studies · 1264 participants	Moderate Downgraded: risk of bias, inconsistency
Preoperative anxiety (STAI) STAI (20 to 80) measured approximately 120 minutes after premedication 20: no anxiety 80: maximum anxiety possible	no estimate extracted	1 study · 44 participants	Very low Downgraded: risk of bias, imprecision, inconsistency
Preoperative anxiety (6‐item STAI) STAI 6‐item (6 to 24) measured approximately 90 minutes after premedication 6: no anxiety 24: maximum anxiety possible	no estimate extracted	1 study · 36 participants	Low Downgraded: risk of bias, imprecision, inconsistency
Immediate postoperative anxiety (VAS) VAS (0 to 100 mm) measured after surgery, in recovery, or at discharge from recovery room 0: no anxiety 100: maximum anxiety possible	no estimate extracted	7 studies · 524 participants	Low Downgraded: risk of bias, imprecision, inconsistency
Delayed postoperative anxiety (STAI) STAI (20 to 80) measured 6 hours after surgery 20: no anxiety 80: maximum anxiety possible	no estimate extracted	2 studies · 73 participants	Low Downgraded: risk of bias, imprecision, inconsistency
Postoperative anxiety (6‐item STAI) STAI 6‐item (6 to 24) measured 1 hour and 6 hours after surgery 6: no anxiety 24: maximum anxiety possible	no estimate extracted	1 study · 36 participants	Low Downgraded: risk of bias, imprecision, inconsistency

Summary of findings

Population: patients undergoing elective surgery

CD009861.PUB3 (current) · 5 questions

Outcome	Effect	Evidence	Status / GRADE
Preoperative anxiety (VAS) VAS (0 to 100 mm) measured approximately 90 minutes after premedication 0: no anxiety 100: maximum anxiety possible	no estimate extracted	7 studies · 409 participants	Moderate Downgraded: risk of bias, inconsistency
Preoperative anxiety (STAI) STAI (20 to 80)	no estimate extracted	NR	No studies
Preoperative anxiety (6‐item STAI) STAI 6‐item (6 to 24) measured approximately 90 minutes after premedication 6: no anxiety 24: maximum anxiety possible	no estimate extracted	1 study · 35 participants	Low Downgraded: risk of bias, imprecision, inconsistency
Immediate postoperative anxiety (VAS) VAS (0 to 100 mm) measured approximately 90 minutes after surgery or in recovery room 0: no anxiety 100: maximum anxiety possible	no estimate extracted	3 studies · 176 participants	Low Downgraded: risk of bias, imprecision, inconsistency
Postoperative anxiety (6‐item STAI) STAI 6‐item (6 to 24) measured 1 hour and 6 hours after surgery 6: no anxiety 24: maximum anxiety possible	no estimate extracted	1 study · 35 participants	Low Downgraded: risk of bias, imprecision, inconsistency

Comparison

Population: Patients undergoing elective surgery

CD009861.PUB2 · 1 question

Outcome	Effect	Evidence	Status / GRADE
VAS (0 to 100 mm) measured approximately 90 min after premedication 0: no anxiety 100: maximum anxiety possible	no estimate extracted	7 studies · 483 participants	High

Comparison

Population: Patients undergoing elective surgery

CD009861.PUB2 · 1 question

Outcome	Effect	Evidence	Status / GRADE
VAS (0 to 100 mm) measured approximately 90 min after premedication 0: no anxiety 100: maximum anxiety possible	no estimate extracted	2 studies · 122 participants	Low Downgraded: risk of bias, imprecision

Comparison

Population: Patients undergoing elective surgery

CD009861.PUB2 · 1 question

Outcome	Effect	Evidence	Status / GRADE
Postoperative anxiety (STAI) Measured 6 hours postoperatively. The range of scores is 20 to 80, the higher scores indicating greater anxiety	no estimate extracted	2 studies · 73 participants	Moderate