Cochrane · systematic review · CD009776
Pharmacological interventions for sleepiness and sleep disturbances caused by shift work
Liira, J, Verbeek, JH, Costa, G, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
WorkAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 75%Moderate 2 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Melatonin versus placebo for sleep disturbances caused by shift work
Population: patients with sleep disturbances caused by shift work
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total sleep time, next day Diaries and actigraphy. Scale from: 120 to 600. Melatonin vs placebo | no estimate extracted | 7 studies · 263 participants | Low Downgraded: risk of bias |
Total sleep time, next night Diaries and actigraphy. Scale from: 120 to 800. Melatonin vs placebo | no estimate extracted | 3 studies · 234 participants | Low |
Sleep onset latency, next day Diaries and actigraphy. Scale from: 0 to 120. Melatonin vs placebo | no estimate extracted | 5 studies · 74 participants | Low Downgraded: risk of bias |
Sleepiness during the night shift KSS Scale from: 1 to 9. Melatonin vs placebo | no estimate extracted | 1 study · 34 participants | Low |
Armodafinil versus placebo for sleepiness caused by shift work
Population: patients with sleepiness caused by shift work
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sleepiness during the night shift KSS at final visit. Scale from: 1 to 9. Armodafinil vs placebo | no estimate extracted | 2 studies · 572 participants | Moderate Downgraded: risk of bias |
Sleep latency MSLT. Scale from: 0 to 20 minutes. Armodafinil vs placebo | no estimate extracted | 1 study · 216 participants | Low |
Modafinil versus placebo for sleepiness caused by shift work
Population: patients with sleepiness caused by shift work
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sleepiness during the night shift KSS. Scale from: 1 to 9. Modafinil vs placebo | no estimate extracted | 1 study · 183 participants | Moderate |
Sleep latency MSLT. Scale from: 0 to 20 minutes. Modafinil vs placebo | no estimate extracted | 1 study · 153 participants | Low |