Cochrane · systematic review · CD009747
Daily iron supplementation for improving anaemia, iron status and health in menstruating women
Low, MSY, Speedy, J, Styles, CE, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Developmental, Psychosocial and Learning ProblemsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
11
current version
GRADE rated
8
No studies
2
Included studies
NR
No studies 2 · 18.2%Ungraded 1 · 9.1%Very low 0 · 0%Low 3 · 27.3%Moderate 2 · 18.2%High 3 · 27.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: menstruating women (non‐pregnant women of reproductive age)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Anaemia at end of therapy (total), as defined by trial authors | RR 0.39 [0.25, 0.6] | 10 studies · 3273 participants | Moderate |
Haemoglobin at end of therapy (total), g/L | MD 5.3 [4.14, 6.45] | 51 studies · 6861 participants | High |
Iron deficiency at end of therapy (total), as defined by trial authors | RR 0.62 [0.5, 0.76] | 7 studies · 1088 participants | Moderate |
Iron‐deficiency anaemia at end of therapy, as defined by trial authors | no estimate extracted | 1 study · 55 participants | Ungraded |
All‐cause mortality, over the course of the study | no estimate extracted | NR | No studies |
Any adverse side effects (total), as defined and reported by trial authors | RR 2.14 [0.94, 4.86] | 7 studies · 901 participants | Low Downgraded: imprecision |
GI side effects (total), events during study, as defined and reported by trial authors | RR 1.99 [1.26, 3.12] | 5 studies · 521 participants | Low Downgraded: imprecision |
Loose stools/diarrhoea (total), events during study, as defined and reported by trial authors | RR 2.13 [1.1, 4.11] | 6 studies · 604 participants | High |
Hard stools/constipation (total), events during study, as defined and reported by trial authors | RR 2.07 [1.35, 3.17] | 8 studies · 1036 participants | High |
Abdominal pain (total), events during study, as defined and reported by trial authors | RR 1.55 [0.99, 2.41] | 7 studies · 1190 participants | Low Downgraded: imprecision |
Cognitive function, as measured by trial authors | no estimate extracted | NR | No studies |