Cochrane · systematic review · CD009700
Deep anterior lamellar keratoplasty versus penetrating keratoplasty for treating keratoconus
Keane, M, Coster, D, Ziaei, M, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
13
current version
GRADE rated
8
No studies
4
Included studies
NR
No studies 4 · 30.8%Ungraded 1 · 7.7%Very low 6 · 46.2%Low 1 · 7.7%Moderate 1 · 7.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: Patients with keratoconus undergoing corneal grafting
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postoperative BCVA (3 months) (LogMAR) | no estimate extracted | NR | No studies |
Postoperative functional BCVA achieved (3 months) Functional BCVA = vision of 0.30 LogMAR or better. As at, 3 months post‐graft | no estimate extracted | NR | No studies |
Postoperative BCVA (12 months) (LogMAR) As at, 12 months post‐graft | no estimate extracted | 1 study · 30 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Postoperative BCVA (post‐suture removal, varied | no estimate extracted | 1 study · 77 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Postoperative functional BCVA achieved (post‐suture removal, varied | OR 0.59 [0.05, 6.77] | 1 study · 77 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Presence of at least one rejection episode As at, post‐suture removal | OR 0.33 [0.14, 0.81] | 2 studies · 111 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Failed graft Including cases where the DALK or PK procedure was unable to be successfully completed as outlined in the methodology for the study | OR 7.52 | 2010 participants | Ungraded |
Summary of findings ‐ Javadi findings only
Population: Patients with keratoconus undergoing corneal grafting
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postoperative BCVA (3 months) (LogMAR) Measured on LogMar scale where normal vision is 0.00. Each line of a LogMAR chart has 5 letters. Each letter is worth 0.02 on the LogMAR scale. A person with vision one full line (five letters) worse than nor... | no estimate extracted | NR | No studies |
Postoperative functional BCVA achieved (3 months) Functional BCVA = vision of 0.30 LogMAR or better. As at, 3 months post‐graft | no estimate extracted | NR | No studies |
Postoperative BCVA (post‐suture removal, varied | no estimate extracted | 1 study · 77 participants | Very low Downgraded: risk of bias, imprecision |
Postoperative functional BCVA achieved (post‐suture removal, varied | OR 0.59 [0.05, 6.77] | 1 study · 77 participants | Very low Downgraded: risk of bias, imprecision |
Presence of at least one rejection episode As at, at least 3 months post‐suture removal | OR 0.37 [0.14, 0.98] | 1 study · 81 participants | Low Downgraded: risk of bias, imprecision |
Failed graft Including cases where the DALK or PK procedure was unable to be successfully completed as outlined in the methodology for the study. As at, at least 3 months post‐suture removal | OR 7.52 [0.39, 144.43] | 1 study · 81 participants | Very low Downgraded: risk of bias, imprecision |