Cochrane · systematic review · CD009634
Intranasal or transdermal nicotine for the treatment of postoperative pain
Matthews, AM, Fu, R, Dana, T, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
AnaesthesiaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 44.4%Low 4 · 44.4%Moderate 1 · 11.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Transdermal or intranasal nicotine versus placebo for the treatment of postoperative pain
Population: people being treated for postoperative pain
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain at 60 minutes Transdermal or intranasal nicotine vs placebo | no estimate extracted | 6 studies · 442 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Pain at 12 hours Transdermal or intranasal nicotine vs placebo | no estimate extracted | 2 studies · 175 participants | Very low Downgraded: risk of bias, imprecision |
Pain at 24 hours Transdermal or intranasal nicotine vs placebo | no estimate extracted | 8 studies · 562 participants | Low Downgraded: risk of bias |
Hourly morphine equivalents at 60 minutes Transdermal or intranasal nicotine vs placebo | no estimate extracted | 4 studies · 168 participants | Low Downgraded: risk of bias, imprecision |
Hourly morphine equivalents at 24 hours Transdermal or intranasal nicotine vs placebo | no estimate extracted | 4 studies · 168 participants | Low Downgraded: risk of bias, imprecision |
Sedation score Transdermal or intranasal nicotine vs placebo | no estimate extracted | 3 studies · 148 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Nausea Transdermal or intranasal nicotine vs placebo | RR 1.24 [1.03, 1.5] | 7 studies · 592 participants | Moderate Downgraded: risk of bias |
Vomiting Transdermal or intranasal nicotine vs placebo | RD 0.03 | 7 studies · 602 participants | Low Downgraded: risk of bias, imprecision |
Time to hospital discharge Transdermal or intranasal nicotine vs placebo | MD 1.2 | 1 study · 90 participants | Very low Downgraded: risk of bias |