Cochrane · systematic review · CD009384
Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years
Imdad, A, Rogner, J, Sherwani, RN, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 5 · 62.5%High 3 · 37.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyZinc supplementation compared to no zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age
Population: otherwise healthy children aged 6 months to 12 years of age
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Zinc supplementation vs no zinc supplementation | RR 0.93 [0.84, 1.03] | 16 studies · 143474 participants | High |
Mortality due to all‐cause diarrhea Zinc supplementation vs no zinc supplementation | RR 0.95 [0.69, 1.31] | 4 studies · 132321 participants | Moderate Downgraded: risk of bias |
Mortality due to LRTI Zinc supplementation vs no zinc supplementation | RR 0.86 [0.64, 1.15] | 3 studies · 132063 participants | Moderate |
Mortality due to malaria Zinc supplementation vs no zinc supplementation | RR 0.9 [0.77, 1.06] | 2 studies · 42818 participants | Moderate |
Incidence of all‐cause diarrhea Zinc supplementation vs no zinc supplementation | RR 0.91 [0.9, 0.93] | 39 studies · 19468 participants | Moderate Downgraded: inconsistency |
Incidence of LRTI Zinc supplementation vs no zinc supplementation | RR 1.01 [0.95, 1.08] | 19 studies · 10555 participants | High |
Height Zinc supplementation vs no zinc supplementation | no estimate extracted | 74 studies · 20720 participants | Moderate Downgraded: risk of bias, inconsistency |
Participants with ≥ 1 vomiting episode Zinc supplementation vs no zinc supplementation | RR 1.29 [1.14, 1.46] | 5 studies · 35192 participants | High |
Zinc versus no zinc for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age
Population: children aged six months to 12 years of age
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Zinc vs no zinc | RR 0.95 [0.86, 1.05] | 14 studies · 138302 participants | High |
Mortality due to all‐cause diarrhoea Zinc vs no zinc | RR 0.95 [0.69, 1.31] | 4 studies · 132321 participants | Moderate |
Mortality due to LRTI Zinc vs no zinc | RR 0.86 [0.64, 1.15] | 3 studies · 132063 participants | Moderate |
Mortality due to malaria Zinc vs no zinc | RR 0.9 [0.77, 1.06] | 2 studies · 42818 participants | Moderate |
Incidence of all‐cause diarrhoea Zinc vs no zinc | RR 0.87 [0.85, 0.89] | 26 studies · 15042 participants | Moderate Downgraded: inconsistency |
Incidence of LRTI Zinc vs no zinc | RR 1 [0.94, 1.07] | 12 studies · 9610 participants | High |
Incidence of malaria Zinc vs no zinc | RR 1.05 [0.95, 1.15] | 4 studies · 2407 participants | Moderate Downgraded: inconsistency |
Height Zinc vs no zinc | no estimate extracted | 50 studies · 13669 participants | Moderate Downgraded: inconsistency |
Participants with 1 vomiting episode Zinc vs no zinc | RR 1.29 [1.14, 1.46] | 5 studies · 35192 participants | High |