Cochrane · systematic review · CD009332
Intravenous versus intramuscular prophylactic oxytocin for reducing blood loss in the third stage of labour
Oladapo, OT, Okusanya, BO, Abalos, E, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 1 · 14.3%Moderate 3 · 42.9%High 2 · 28.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyIntravenous compared to intramuscular oxytocin for PPH prevention
Population: women in the 3rd stage of labour undergoing a vaginal birth.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Severe PPH ≥ 1000 mL Intravenous vs intramuscular oxytocin | RR 0.65 [0.39, 1.08] | 4 studies · 6681 participants | Moderate Downgraded: imprecision |
Serious maternal morbidity Intravenous vs intramuscular oxytocin | RR 0.47 [0.22, 1] | 4 studies · 7028 participants | Moderate Downgraded: imprecision |
Maternal death Intravenous vs intramuscular oxytocin | no estimate extracted | 4 studies · 7028 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
PPH ≥ 500 mL Intravenous vs intramuscular oxytocin | RR 0.78 [0.66, 0.92] | 6 studies · 7731 participants | High |
Use of additional uterotonics Intravenous vs intramuscular oxytocin | RR 0.78 [0.49, 1.25] | 6 studies · 7327 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Blood transfusion Intravenous vs intramuscular oxytocin | RR 0.44 [0.26, 0.77] | 4 studies · 6684 participants | High |
Hypotension Intravenous vs intramuscular oxytocin | RR 1.01 [0.88, 1.15] | 4 studies · 6468 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Intramuscular compared to intravenous prophylactic oxytocin in the third stage of labour
Population: women in the third stage of labour (just after delivery of the anterior shoulder or birth of the baby and cord clamping)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Severe PPH (blood loss ≥ 1000 mL) Intramuscular vs intravenous prophylactic oxytocin | RR 0.11 [0.01, 2.04] | 1 study · 256 participants | Very low Downgraded: risk of bias, imprecision |
Serious maternal morbidity: hysterectomy Intramuscular vs intravenous prophylactic oxytocin | no estimate extracted | 1 study · 600 participants | Very low Downgraded: risk of bias, imprecision |
Blood transfusion Intramuscular vs intravenous prophylactic oxytocin | RR 1 [0.06, 15.82] | 1 study · 256 participants | Very low Downgraded: risk of bias, imprecision |
Maternal death Intramuscular vs intravenous prophylactic oxytocin | no estimate extracted | 0 studies · 0 participants | Ungraded |
Maternal major adverse effects: hypotension Intramuscular vs intravenous prophylactic oxytocin | no estimate extracted | 0 studies · 0 participants | Ungraded |
Maternal dissatisfaction with intervention Intramuscular vs intravenous prophylactic oxytocin | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neonatal jaundice Intramuscular vs intravenous prophylactic oxytocin | no estimate extracted | 0 studies · 0 participants | Ungraded |