Cochrane · systematic review · CD009258
Clobazam monotherapy for focal or generalized seizures
Arya, R, Giridharan, N, Anand, V, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
6
No studies
6
Included studies
NR
No studies 6 · 50%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 50%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyClobazam versus carbamazepine for focal or generalized seizures
Population: people with focal or generalized seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time on allocated treatment (retention time) Clobazam vs carbamazepine | no estimate extracted | NR | No studies |
Retention at 12 months Clobazam vs carbamazepine | RR 0.83 [0.61, 1.12] | 1 study · 115 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Seizure freedom at 4 weeks Clobazam vs carbamazepine | RR 0.85 [0.55, 1.32] | 1 study · 43 participants | Low Downgraded: imprecision, inconsistency, publication bias |
Seizure freedom 4‐40 weeks Clobazam vs carbamazepine | RR 0.95 [0.66, 1.36] | 1 study · 43 participants | Low Downgraded: imprecision, inconsistency, publication bias |
50% responder rate Clobazam vs carbamazepine | RR 1.18 [0.94, 1.48] | 1 study · 43 participants | Low Downgraded: imprecision, inconsistency, publication bias |
Adverse effects requiring withdrawal/discontinuation of study medication Clobazam vs carbamazepine | no estimate extracted | NR | No studies |
Clobazam versus phenytoin for focal or generalized seizures
Population: drug‐naïve people with focal or generalized seizures with solitary cysticercus granuloma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time on allocated treatment (retention time) Clobazam vs phenytoin | no estimate extracted | NR | No studies |
Retention at 6 months (measured by the number of treatment failures in each group, which was defined as either breakthrough seizure or adverse effects requiring discontinuation or dose modification of study medication) Clobazam vs phenytoin | RR 1.43 [1.08, 1.9] | 1 study · 48 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Seizure freedom at 4 weeks Clobazam vs phenytoin | no estimate extracted | NR | No studies |
Seizure freedom 4‐40 weeks Clobazam vs phenytoin | no estimate extracted | NR | No studies |
50% responder rate Clobazam vs phenytoin | no estimate extracted | NR | No studies |
Adverse effects requiring withdrawal/discontinuation of study medication Clobazam vs phenytoin | RR 0.1 [0.01, 1.65] | 1 study · 48 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Clobazam versus carbamazepine for partial‐onset or generalized‐onset seizures
Population: patients with partial‐onset or generalized‐onset seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Retention at 12 months Clobazam vs carbamazepine | RR 0.83 [0.61, 1.12] | 1 study · 115 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Clobazam versus phenytoin for partial‐onset or generalized‐onset seizures
Population: Drug‐naïve patients with partial‐onset or generalized‐onset seizures with solitary cysticercus granuloma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Retention at 6 months (Measured by the number of treatment failures in each group, which was defined as either breakthrough seizure or adverse effects requiring discontinuation or dose modification of study medication) Clobazam vs phenytoin | RR 1.43 [1.08, 1.9] | 1 study · 48 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Adverse effects requiring withdrawal/ discontinuation of study medication Clobazam vs phenytoin | RR 0.1 [0.01, 1.65] | 1 study · 48 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |