Cochrane · systematic review · CD009191
Angiotensin‐converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease
Sasongko, TH, Nagalla, S · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 6 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyACE inhibitors compared with placebo for proteinuria and microalbuminuria in people with sickle cell disease
Population: adults and children with proteinuria or microalbuminuria due to sickle cell disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Urinary protein or albumin excretion ‐ total albumin excretion at 6 months ACE inhibitors vs placebo | no estimate extracted | 1 study · 22 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Serum creatinine ACE inhibitors vs placebo | no estimate extracted | 1 study · 22 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Electrolyte levels ACE inhibitors vs placebo | no estimate extracted | 1 study · 22 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Mean blood pressure (mmHg) ACE inhibitors vs placebo | no estimate extracted | 1 study · 22 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Hemoglobin concentration (g/dL) ACE inhibitors vs placebo | no estimate extracted | 1 study · 22 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Any reported adverse effect or toxicity ACE inhibitors vs placebo | no estimate extracted | 1 study · 22 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Comparison
Population: People with proteinuria or microalbuminuria due to sickle cell disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Albumin excretion in 1 month (mg/day) | no estimate extracted | 1 study · 22 participants | High |
Albumin excretion in 3 months (mg/day) | no estimate extracted | 1 study · 22 participants | High |
Albumin excretion in 6 months (mg/day) | no estimate extracted | 1 study · 22 participants | High |
Serum creatinine (umol/L) | no estimate extracted | 1 study · 22 participants | High |
Sodium | no estimate extracted | 1 study · 22 participants | Ungraded |
Potassium | no estimate extracted | 1 study · 22 participants | High |
Mean blood pressure (mmHg) | no estimate extracted | 1 study · 22 participants | High |
Systolic blood pressure (mmHg) | no estimate extracted | 1 study · 22 participants | High |
Diastolic blood pressure (mmHg) | no estimate extracted | 1 study · 22 participants | High |
Hemoglobin concentration (g/dL) | no estimate extracted | 1 study · 22 participants | High |
Dry cough | no estimate extracted | 1 study · 22 participants | High |
Pain in shoulder | no estimate extracted | 1 study · 22 participants | High |
Clinical proteinuria | no estimate extracted | 1 study · 22 participants | High |