Cochrane · systematic review · CD009131
Neuropsychological rehabilitation for multiple sclerosis
Rosti‐Otajärvi, EM, Hämäläinen, PI · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 50%Low 5 · 35.7%Moderate 2 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyCognitive training versus any control for multiple sclerosis
Population: patients with multiple sclerosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Attention Cognitive training vs any control | SMD 0.06 | 5 studies · 573 participants | Low Downgraded: risk of bias |
Information processing speed Cognitive training vs any control | SMD 0.15 | 4 studies · 176 participants | Very low Downgraded: risk of bias, inconsistency |
Memory span Cognitive training vs any control | SMD 0.54 [0.2, 0.88] | 2 studies · 150 participants | Low Downgraded: risk of bias |
Working memory Cognitive training vs any control | SMD 0.33 [0.09, 0.57] | 3 studies · 288 participants | Very low Downgraded: risk of bias |
Immediate verbal memory Cognitive training vs any control | SMD 0.2 | 4 studies · 360 participants | Low Downgraded: risk of bias |
Executive functions Cognitive training vs any control | SMD 0.35 | 2 studies · 112 participants | Very low Downgraded: risk of bias |
Depression Cognitive training vs any control | SMD 0.26 | 5 studies · 196 participants | Very low Downgraded: risk of bias, inconsistency |
Cognitive training combined with other neuropsychological rehabilitation methods versus any control for multiple sclerosis
Population: patients with multiple sclerosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Attention Cognitive training combined with other neuropsychological rehabilitation methods vs any control | SMD 0.15 [0.01, 0.28] | 5 studies · 894 participants | Moderate Downgraded: risk of bias |
Information processing speed Cognitive training combined with other neuropsychological rehabilitation methods vs any control | SMD 0.05 | 3 studies · 181 participants | Very low Downgraded: risk of bias |
Immediate verbal memory Cognitive training combined with other neuropsychological rehabilitation methods vs any control | SMD 0.31 [0.08, 0.54] | 7 studies · 308 participants | Very low Downgraded: risk of bias |
Delayed memory Cognitive training combined with other neuropsychological rehabilitation methods vs any control | SMD 0.22 [0.02, 0.42] | 4 studies · 400 participants | Moderate Downgraded: risk of bias |
Everyday cognitive performance/patient's report Cognitive training combined with other neuropsychological rehabilitation methods vs any control | SMD 0.1 | 4 studies · 1011 participants | Low Downgraded: risk of bias, inconsistency |
Depression Cognitive training combined with other neuropsychological rehabilitation methods vs any control | MD 0.25 | 4 studies · 187 participants | Low Downgraded: risk of bias, inconsistency |
Fatigue Cognitive training combined with other neuropsychological rehabilitation methods vs any control | SMD 0.08 | 3 studies · 159 participants | Very low Downgraded: risk of bias, inconsistency |
Cognitive training for Multiple sclerosis
Population: patients with Multiple sclerosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Attention | no estimate extracted | 4 studies · 488 participants | Low Downgraded: risk of bias |
Information processing speed | no estimate extracted | 4 studies · 176 participants | Very low Downgraded: risk of bias, inconsistency |
Memory span | no estimate extracted | 2 studies · 150 participants | Low Downgraded: risk of bias |
Working memory | no estimate extracted | 3 studies · 288 participants | Very low Downgraded: risk of bias |
Immediate visual memory | no estimate extracted | 3 studies · 217 participants | Low Downgraded: risk of bias |
Executive functions | no estimate extracted | 2 studies · 112 participants | Very low Downgraded: risk of bias |
Depression | no estimate extracted | 4 studies · 173 participants | Very low Downgraded: risk of bias, inconsistency |
Cognitive training combined with other neuropsychological rehabilitation methods for Multiple sclerosis
Population: patients with Multiple sclerosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Attention | no estimate extracted | 2 studies · 103 participants | Low Downgraded: risk of bias |
Information processing speed | no estimate extracted | 3 studies · 181 participants | Very low Downgraded: risk of bias |
Immediate verbal memory | no estimate extracted | 4 studies · 129 participants | Very low Downgraded: risk of bias |
Executive functions | no estimate extracted | 2 studies · 99 participants | Very low Downgraded: risk of bias |
Everyday cognitive performance / patient's report | no estimate extracted | 2 studies · 693 participants | Moderate Downgraded: risk of bias |
Depression | no estimate extracted | 3 studies · 89 participants | Low Downgraded: risk of bias |
Fatigue | no estimate extracted | 2 studies · 61 participants | Low Downgraded: risk of bias |