Cochrane · systematic review · CD009043

Aripiprazole for autism spectrum disorders (ASD)

Hirsch, LE, Pringsheim, T · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library

Developmental, Psychosocial and Learning Problems2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 6 · 85.7%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Current version only

Comparison

Population: children/youth with ASD

CD009043.PUB3 (current) · 7 questions

Outcome	Effect	Evidence	Status / GRADE
ABC ‐ Irritability subscale Mean score changes 8 weeks of treatment	no estimate extracted	2 studies · 308 participants	Moderate Downgraded: risk of bias, imprecision
ABC ‐ Hyperactivity subscale Mean score changes 8 weeks of treatment	no estimate extracted	2 studies · 308 participants	Moderate Downgraded: risk of bias, imprecision
ABC ‐ Stereotypy subscale Mean score changes 8 weeks of treatment	no estimate extracted	2 studies · 308 participants	Moderate Downgraded: risk of bias, imprecision
Weight gain 8 weeks of treatment	no estimate extracted	2 studies · 308 participants	Moderate Downgraded: risk of bias, imprecision
Sedation 8 weeks of treatment	no estimate extracted	2 studies · 313 participants	Moderate Downgraded: risk of bias, imprecision
Tremor 8 weeks of treatment	no estimate extracted	2 studies · 313 participants	Moderate Downgraded: risk of bias, imprecision
Relapse rate 16 weeks of treatment	no estimate extracted	1 study · 85 participants	Low Downgraded: risk of bias

Comparison

Population: Children/youth with ASD

CD009043.PUB2 · 6 questions

Outcome	Effect	Evidence	Status / GRADE
ABC Irritability Subscale Mean Score Changes 8 weeks of treatment	no estimate extracted	2 studies · 308 participants	Moderate
ABC Hyperactivity Subscale Mean Score Changes 8 weeks of treatment	no estimate extracted	2 studies · 308 participants	Moderate
ABC Stereotypy Subscale Mean Score Changes 8 weeks of treatment	no estimate extracted	2 studies · 308 participants	Moderate
Weight Gain 8 weeks of treatment	no estimate extracted	2 studies · 308 participants	Moderate
Sedation 8 weeks of treatment	no estimate extracted	2 studies · 313 participants	Moderate
Tremor 8 weeks of treatment	no estimate extracted	2 studies · 313 participants	Moderate