Cochrane · systematic review · CD008841
Lacosamide add‐on therapy for focal epilepsy
Babar, RK, Bresnahan, R, Gillespie, CS, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 4 · 57.1%High 2 · 28.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyAny dose of lacosamide compared to placebo as add‐on therapy for drug‐resistant focal epilepsy
Population: adults and children with drug‐resistant focal epilepsy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
50% or greater reduction in seizure frequency Any dose of lacosamide vs placebo | RR 1.79 [1.55, 2.08] | 5 studies · 2199 participants | High |
Seizure freedom Any dose of lacosamide vs placebo | RR 2.27 [1.35, 3.83] | 5 studies · 2199 participants | Low Downgraded: imprecision |
Treatment withdrawal Any dose of lacosamide vs placebo | RR 1.57 [1.24, 1.98] | 5 studies · 2199 participants | Moderate Downgraded: imprecision |
Dizziness Any dose of lacosamide vs placebo | RR 2.96 | 5 studies · 2199 participants | High |
Headache Any dose of lacosamide vs placebo | RR 1.34 | 5 studies · 2199 participants | Moderate Downgraded: imprecision |
Vomiting Any dose of lacosamide vs placebo | RR 2.94 | 5 studies · 2199 participants | Moderate Downgraded: imprecision |
Serious adverse events Any dose of lacosamide vs placebo | RR 1.53 | 5 studies · 2199 participants | Moderate Downgraded: imprecision |
Lacosamide compared with placebo for partial epilepsy
Population: people with partial epilepsy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
50% reduction in seizure frequency ‐ lacosamide any dose Lacosamide vs placebo | RR 1.7 [1.38, 2.1] | 3 studies · 1294 participants | High |
Seizure freedom ‐ lacosamide any dose Lacosamide vs placebo | RR 2.5 [0.85, 7.34] | 3 studies · 1294 participants | Moderate Downgraded: imprecision |
Treatment withdrawals ‐ lacosamide any dose Lacosamide vs placebo | RR 1.88 [1.4, 2.52] | 3 studies · 1308 participants | High |