Cochrane · systematic review · CD008806
Osmotic therapies added to antibiotics for acute bacterial meningitis
Wall, ECB, Ajdukiewicz, KMB, Bergman, H, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 16.7%Low 2 · 33.3%Moderate 3 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyGlycerol for acute bacterial meningitis
Population: children and adults with acute bacterial meningitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death | RR 1.08 [0.9, 1.3] | 5 studies · 1272 participants | Moderate Downgraded: risk of bias, inconsistency |
Neurological disability | RR 0.73 [0.53, 1] | 5 studies · 1270 participants | Low Downgraded: risk of bias |
Seizures | RR 1.08 [0.9, 1.3] | 4 studies · 1090 participants | Low Downgraded: risk of bias |
Hearing loss | RR 0.64 [0.44, 0.93] | 5 studies · 922 participants | Moderate Downgraded: risk of bias, inconsistency |
Adverse effects: nausea, vomiting, diarrhoea | RR 1.09 [0.81, 1.47] | 2 studies · 851 participants | Very low Downgraded: risk of bias |
Adverse effects: gastrointestinal bleeding | RR 0.93 [0.39, 2.19] | 3 studies · 607 participants | Moderate Downgraded: risk of bias, inconsistency |
Glycerol for acute bacterial meningitis
Population: acute bacterial meningitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death | RR 1.09 [0.89, 1.33] | 4 studies · 1091 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Neurological disability | RR 0.8 [0.46, 1.38] | 3 studies · 732 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Seizures | RR 1.08 [0.9, 1.3] | 3 studies · 909 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Hearing loss | RR 0.6 [0.38, 0.93] | 3 studies · 741 participants | Low Downgraded: risk of bias, imprecision |