Cochrane · systematic review · CD008726
Different classes of antibiotics given to women routinely for preventing infection at caesarean section
Williams, MJ, Carvalho Ribeiro do Valle, C, Gyte, GML · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 28.6%Very low 4 · 57.1%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyAntistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) compared to broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes for preventing infection at caesarean section
Population: all women undergoing caesarean section
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal sepsis Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes | RR 2.37 [0.1, 56.41] | 1 study · 75 participants | Very low Downgraded: risk of bias |
Maternal endometritis Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes | RR 1.1 [0.76, 1.6] | 7 studies · 1161 participants | Low Downgraded: risk of bias |
Infant sepsis Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes | no estimate extracted | 0 studies · 0 participants | Ungraded |
Infant oral thrush Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes | no estimate extracted | 0 studies · 0 participants | Ungraded |
Maternal wound infection Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes | RR 0.78 [0.32, 1.9] | 4 studies · 543 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Maternal urinary tract infection Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes | RR 0.64 [0.11, 3.73] | 4 studies · 496 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Maternal composite adverse effects Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes | RR 0.96 [0.09, 10.5] | 2 studies · 468 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Cephalosporins versus penicillins ‐ all women for preventing infection at caesarean section
Population: Women undergoing caesarean section.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal sepsis ‐ Single cephalosporin vs single penicillin Cephalosporins vs penicillins ‐ all women | no estimate extracted | 2 studies · 346 participants | Ungraded |
Maternal endometritis ‐ Single cephalosporin vs single penicillin Cephalosporins vs penicillins ‐ all women | RR 1.11 [0.81, 1.52] | 9 studies · 3130 participants | Moderate |
Infant sepsis ‐ Single cephalosporin vs single penicillin Cephalosporins vs penicillins ‐ all women | no estimate extracted | 0 studies · 0 participants | Ungraded |
Infant oral thrush ‐ Single cephalosporin vs single penicillin Cephalosporins vs penicillins ‐ all women | no estimate extracted | 0 studies · 0 participants | Ungraded |
Maternal wound infection ‐ Single cephalosporin vs single penicillin Cephalosporins vs penicillins ‐ all women | RR 0.83 [0.38, 1.81] | 9 studies · 1497 participants | Low Downgraded: imprecision |
Maternal urinary tract infection ‐ Single cephalosporin vs single penicillin Cephalosporins vs penicillins ‐ all women | RR 1.48 [0.89, 2.48] | 7 studies · 1120 participants | Low Downgraded: imprecision |
Maternal composite adverse effects ‐ Single cephalosporin vs single penicillin Cephalosporins vs penicillins ‐ all women | RR 2.02 [0.18, 21.96] | 3 studies · 1902 participants | Very low Downgraded: imprecision |