Cochrane · systematic review · CD008666
Vitamin A supplementation during pregnancy for maternal and newborn outcomes
McCauley, ME, van den Broek, N, Dou, L, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 10%Very low 0 · 0%Low 5 · 50%Moderate 1 · 10%High 3 · 30%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyVitamin A alone versus placebo or no treatment
Population: Pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal mortality Vitamin A alone vs placebo or no treatment | RR 0.88 [0.65, 1.2] | 4 studies · 154039 participants | High |
Perinatal mortality Vitamin A alone vs placebo or no treatment | RR 1.01 [0.95, 1.07] | 1 study · 76176 participants | High |
Maternal anaemia Vitamin A alone vs placebo or no treatment | RR 0.64 [0.43, 0.94] | 3 studies · 15649 participants | Moderate Downgraded: risk of bias, inconsistency |
Maternal clinical infection Vitamin A alone vs placebo or no treatment | RR 0.45 [0.2, 0.99] | 5 studies · 17313 participants | Low Downgraded: risk of bias, inconsistency |
Preterm birth Vitamin A alone vs placebo or no treatment | RR 0.98 [0.94, 1.01] | 5 studies · 48007 participants | High |
Combination vitamin A and micronutrients for maternal and newborn mortality and morbidity
Population: Pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal mortality | no estimate extracted | 0 studies · 0 participants | Ungraded |
Perinatal mortality | RR 0.51 [0.1, 2.69] | 1 study · 179 participants | Low Downgraded: imprecision |
Maternal anaemia | RR 0.86 [0.68, 1.09] | 3 studies · 706 participants | Low Downgraded: imprecision |
Maternal clinical infection | RR 0.95 [0.8, 1.13] | 2 studies · 597 participants | Low Downgraded: imprecision |
Preterm birth | RR 0.39 [0.08, 1.93] | 1 study · 136 participants | Low Downgraded: imprecision |
Vitamin A for maternal and newborn mortality and morbidity
Population: Pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal mortality | RR 0.78 [0.55, 1.1] | 3 studies · 94373 participants | High |
Perinatal mortality | RR 1.01 [0.95, 1.07] | 1 study · 76176 participants | High |
Preterm birth | RR 0.77 [0.57, 1.04] | 4 studies · 1937 participants | Low |
Maternal anaemia | RR 0.64 [0.43, 0.94] | 3 studies · 2401 participants | High |
Maternal infection | RR 0.37 [0.18, 0.77] | 3 studies · 1458 participants | Low Downgraded: risk of bias |
Combination vitamin A and micronutrients for maternal and newborn mortality and morbidity
Population: Pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal mortality | no estimate extracted | 0 studies · 0 participants | Ungraded |
Perinatal mortality | no estimate extracted | 0 studies · 0 participants | Ungraded |
Preterm birth | RR 0.39 [0.08, 1.93] | 1 study · 136 participants | Very low Downgraded: risk of bias, publication bias |
Maternal anaemia | RR 0.86 [0.68, 1.09] | 3 studies · 706 participants | Low Downgraded: risk of bias |
Maternal infection | no estimate extracted | 0 studies · 0 participants | Ungraded |