Cochrane · systematic review · CD008652
Pharmacotherapy for hyperuricaemia in hypertensive patients
Gois, PHenrique França, Souza, ERegio de Moraes · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 83.3%Moderate 0 · 0%High 1 · 16.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyUric acid‐lowering drug compared to placebo for people with hyperuricaemia
Population: hyperuricaemia in people with hypertension
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
24‐h ambulatory systolic BP Uric acid‐lowering drug vs placebo | no estimate extracted | 3 studies · 229 participants | Low Downgraded: imprecision, inconsistency |
24‐h ambulatory diastolic BP Uric acid‐lowering drug vs placebo | no estimate extracted | 3 studies · 229 participants | Low Downgraded: imprecision, inconsistency |
Clinic‐measured systolic BP Uric acid‐lowering drug vs placebo | no estimate extracted | 2 studies · 120 participants | Low Downgraded: imprecision, inconsistency |
Clinic‐measured diastolic BP Uric acid‐lowering drug vs placebo | no estimate extracted | 2 studies · 120 participants | Low Downgraded: imprecision, inconsistency |
Serum UA Uric acid‐lowering drug vs placebo | no estimate extracted | 3 studies · 223 participants | High |
Adverse events (withdrawals due to side effects) Uric acid‐lowering drug vs placebo | RR 1.86 [0.43, 8.1] | 3 studies · 241 participants | Low Downgraded: imprecision |
Uric acid (UA) lowering drug compared to placebo for hyperuricemia in hypertensive patients
Population: hyperuricemia in hypertensive patients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
24h‐Systolic Blood Pressure Uric acid (UA) lowering drug vs placebo | no estimate extracted | 3 studies · 229 participants | Low Downgraded: imprecision |
24h‐Diastolic Blood Pressure Uric acid (UA) lowering drug vs placebo | no estimate extracted | 3 studies · 229 participants | Low Downgraded: imprecision |
Clinic Systolic Blood Pressure Uric acid (UA) lowering drug vs placebo | no estimate extracted | 2 studies · 120 participants | Low Downgraded: imprecision |
Clinic Diastolic Blood Pressure Uric acid (UA) lowering drug vs placebo | no estimate extracted | 2 studies · 120 participants | Low Downgraded: imprecision |
Serum uric acid Uric acid (UA) lowering drug vs placebo | no estimate extracted | 3 studies · 223 participants | High |
Withdrawals due to adverse effects Uric acid (UA) lowering drug vs placebo | RR 1.86 [0.43, 8.1] | 3 studies · 241 participants | Very low Downgraded: imprecision |
. Allopurinol for hypertension
Population: Adolescents (11 ‐ 17 years) newly diagnosed stage I primary hypertension and with SUA > 6mg/d
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in systolic casual blood pressure Allopurinol Placebo P = 0.009 Change in diastolic casual blood pressure Allopurinol Placebo P = 0.05 Change in systolic ambulatory blood pressure Allopurinol Placebo P = 0.001 Change in diastolic ambulatory... | no estimate extracted | 1 study · 30 participants | Low |